Compound Q&A
How is 5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 53786-28-0) typically synthesized?
Answer
This compound is typically synthesized via the condensation of 5-chlorobenzimidazole with 4-piperidinecarboxylic acid, followed by a coupling reaction using a suitable coupling reagent like 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The reaction requires basic conditions and is conducted with good selectivity and yield, often over 90%.
About
CAS No
53786-28-0
English Name
5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one
Molecular Formula
C12H14ClN3O
Molecular Weight
251.72 g/mol
SMILES
C1CNCCC1N2C3=C(C=C(C=C3)Cl)NC2=O
InChIKey
DOAYWDKFDPSTSV-UHFFFAOYSA-N
Last Updated: 2025-09-10 15:15