2-Thiophenecarbonyl chloride

Basic Information

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CAS Number

5271-67-0

Molecular Formula

C5H3ClOS

Molecular Weight

146.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Boiling Point

190°C

Refractive Index

n20/D 1.590(lit.)

SMILES

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C1=CSC(=C1)C(=O)Cl

InChI

InChI=1S/C5H3ClOS/c6-5(7)4-2-1-3-8-4/h1-3H

InChIKey

QIQITDHWZYEEPA-UHFFFAOYSA-N

LogP

2.1271000000000004

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

105

Safety Information

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Hazard Statement

H227 Combustible liquid
Flammable liquids

H290 May be corrosive to metals
Corrosive to Metals

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

2-thienoyl chloride
PS-10803
MFCD00005428
2-Thiophenzoyl Chloride
.alpha.-Thenoyl chloride
Z168827498
2-thiophencarbonylchloride
2-Thiophenecarbonylchloride
thenoyl chloride
thiophenecarbonyl chloride
EN300-24041
thiophene carboxylic acid chloride
SCHEMBL1813
T0177
thiopene-2-carbonyl chloride
2-Thiophenecarbonyl chloride, technical, >=97.0% (AT)
D78154
thiophene carbonyl chloride
DTXSID4063749
W-202994
2-thiophene carbonyl chloride
thiophene-2-carbonylchloride
2-Thiophencarbonyl chloride
EINECS 226-092-4
a-Thenoyl chloride
2-thenoyl-chloride
5271-67-0
NS00009061
thiophen-2-carbonyl chloride
Thiophene-2-carbonyl chloride
AKOS000268690

MDL Number

MFCD00005428

Customs Code

29349990

FAQ

What are the physical and chemical properties of 2-Thiophenecarbonyl chloride (CAS: 5271-67-0)?

2-Thiophenecarbonyl chloride is a crystalline compound with a molecular weight of approximately 155.57 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. It is a reactive compound, prone to hydrolysis to form thiophene carboxylic acid. The compound is sensitive to moisture and air, and it is typically stored in a desiccant-sealed container.

How is 2-Thiophenecarbonyl chloride (CAS: 5271-67-0) typically synthesized?

2-Thiophenecarbonyl chloride can be synthesized by reacting thiophene with phosgene in the presence of a suitable catalyst, such as aluminum chloride. The reaction is exothermic and requires careful control of temperature to achieve high yield and selectivity. The product is typically purified by recrystallization or distillation.

What industries use 2-Thiophenecarbonyl chloride (CAS: 5271-67-0)?

2-Thiophenecarbonyl chloride finds applications in various industries. It is used in the synthesis of functionalized thiophene derivatives, which are important in pharmaceuticals, such as in the development of anti-inflammatory drugs. It also plays a role in the production of polymers and as a precursor in the manufacturing of sensors and semiconductors.

What precautions should be taken when handling 2-Thiophenecarbonyl chloride (CAS: 5271-67-0)?

When handling 2-Thiophenecarbonyl chloride, it is essential to take appropriate safety precautions. Wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood. Handle the compound in a fume hood to minimize exposure to its fumes. Store it in a cool, dry place, away from moisture and direct sunlight. In case of a spill, follow the emergency response procedures outlined in the safety data sheet (SDS).