6-Methoxyquinoline

Basic Information

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CAS Number

5263-87-6

Molecular Formula

C10H9NO

Molecular Weight

159.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

18-20 °C

Boiling Point

140-146 °C/15 mmHg

Refractive Index

n20/D 1.625(lit.)

SMILES

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COC1=CC2=C(C=C1)N=CC=C2

InChI

InChI=1S/C10H9NO/c1-12-9-4-5-10-8(7-9)3-2-6-11-10/h2-7H,1H3

InChIKey

HFDLDPJYCIEXJP-UHFFFAOYSA-N

LogP

2.2434000000000003

pKa

5.03(at 20℃)

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

149

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Sensitiveness

Light Sensitive

Synonyms & References

English

5263-87-6
AMY21891
Methyl 6-quinolyl ether
WLN: T66 BNJ HO1
6-Methoxy-quinoline
CS-W017948
HY-W017232
BDBM50047014
MFCD00006800
6-methoxy quinoline
5S1U3125AD
A26233
FT-0621202
NSC1954
NS00014569
AI3-16316
6-Methoxyquinoline, 98%
UNII-5S1U3125AD
AKOS000121104
6-methoxyquinolin
NSC 1954
H10211
DTXSID9063746
STR09836
SCHEMBL12015264
AC-18179
M0891
Q27140168
CHEBI:72822
EN300-23867
SY012831

MDL Number

MFCD00006800

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 6-Methoxyquinoline (CAS: 5263-87-6)?

6-Methoxyquinoline is a crystalline compound with a molecular weight of 158.17 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly in nucleophilic substitution reactions. It is stable under normal conditions but should be stored away from strong acids and bases.

How is 6-Methoxyquinoline (CAS: 5263-87-6) typically synthesized?

6-Methoxyquinoline is commonly synthesized via the methylation of 5-hydroxyquinoline. The reaction is catalyzed by phosphoric acid and typically proceeds with high yield and good selectivity. Other methods include the reduction of 7-chloro-6-methoxyquinoline with sodium borohydride, which gives the desired product with high purity.

What industries use 6-Methoxyquinoline (CAS: 5263-87-6)?

6-Methoxyquinoline is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the development of antifungal and antiparasitic drugs. It is also used in the production of dyes, pigments, and as a precursor in the development of semiconductors and electronic materials.

What precautions should be taken when handling 6-Methoxyquinoline (CAS: 5263-87-6)?

When handling 6-Methoxyquinoline, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly rinsed. Refer to the Safety Data Sheet (SDS) for detailed guidelines on handling, storage, and disposal.