6-Methoxyquinoline(CAS: 5263-87-6)

6-Methoxyquinoline is a crystalline compound with a molecular weight of 158.17 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly in nucleophilic substitution reactions. It is stable under normal conditions but should be stored away from strong acids and bases.

6-Methoxyquinoline is commonly synthesized via the methylation of 5-hydroxyquinoline. The reaction is catalyzed by phosphoric acid and typically proceeds with high yield and good selectivity. Other methods include the reduction of 7-chloro-6-methoxyquinoline with sodium borohydride, which gives the desired product with high purity.

6-Methoxyquinoline is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the development of antifungal and antiparasitic drugs. It is also used in the production of dyes, pigments, and as a precursor in the development of semiconductors and electronic materials.

When handling 6-Methoxyquinoline, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly rinsed. Refer to the Safety Data Sheet (SDS) for detailed guidelines on handling, storage, and disposal.