(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide | CAS No. 521284-19-5
(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide
Basic Information
CAS Number
521284-19-5
Molecular Formula
C16H16N2O4
Molecular Weight
300.31 g/mol
AD
Basic Physical Properties
Boiling Point
584.8°C at 760 mmHg
Density
1.294
Safety Information
View Safety InformationGHS Hazard Pictograms
H302Hazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
Synonyms & References
English
- Benzeneacetamide, ?-hydroxy-N-[2-(4-nitrophenyl)ethyl]-, (?R)-
- Benzeneacetamide, -hydroxy-N-[2-(4-nitrophenyl)ethyl]-, (R)-
- (R)-2-Hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide
- (2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide
- (alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide
- (R)-2-HYDROXY-N-[2-(4-NITROPHENYL)ETHYL]-2-PHENYLACETAMIDE
- (R)-N-(4-nitrophenethyl)-2-hydroxy-2-phenylacetamide
- Mirabegron Intermediate 1
- (R)-2-hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide
MDL Number
MFCD22200231
FAQ
What are the physical and chemical properties of (2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide (CAS: 521284-19-5)?
(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide is a white or off-white crystalline solid with a molecular weight of approximately 320.24 g/mol. It is slightly soluble in water and more soluble in organic solvents. The compound is chemically reactive, particularly towards nucleophiles and bases. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.
How is (2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide (CAS: 521284-19-5) typically synthesized?
(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide is typically synthesized via a multi-step process involving a condensation reaction between 4-nitrophenyl acetic acid and phenylacetic acid. The reaction is often catalyzed by a strong acid such as hydrochloric acid, and the yield can be improved by optimizing reaction conditions such as temperature and concentration. The product is then purified by recrystallization from a suitable solvent.
What industries use (2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide (CAS: 521284-19-5)?
(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide has applications in the pharmaceutical industry, particularly in the synthesis of certain medicaments. It is also used in the chemical industry for the production of other organic compounds and in research and development for its reactivity and utility in various chemical transformations.
What precautions should be taken when handling (2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide (CAS: 521284-19-5)?
When handling (2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of spill, the area should be cleaned with water and appropriate cleaning agents. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions. Storage should be in a cool, dry place away from flammable materials and direct sunlight.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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