(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide(CAS: 521284-19-5)

(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide is a white or off-white crystalline solid with a molecular weight of approximately 320.24 g/mol. It is slightly soluble in water and more soluble in organic solvents. The compound is chemically reactive, particularly towards nucleophiles and bases. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide is typically synthesized via a multi-step process involving a condensation reaction between 4-nitrophenyl acetic acid and phenylacetic acid. The reaction is often catalyzed by a strong acid such as hydrochloric acid, and the yield can be improved by optimizing reaction conditions such as temperature and concentration. The product is then purified by recrystallization from a suitable solvent.

(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide has applications in the pharmaceutical industry, particularly in the synthesis of certain medicaments. It is also used in the chemical industry for the production of other organic compounds and in research and development for its reactivity and utility in various chemical transformations.

When handling (2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of spill, the area should be cleaned with water and appropriate cleaning agents. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions. Storage should be in a cool, dry place away from flammable materials and direct sunlight.