Compound Q&A
How is (2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide (CAS: 521284-19-5) typically synthesized?
Answer
![(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide](https://static.chemtradehub.com/structs/521/521284-19-5-6a6e.webp "(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide")
(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide is typically synthesized via a multi-step process involving a condensation reaction between 4-nitrophenyl acetic acid and phenylacetic acid. The reaction is often catalyzed by a strong acid such as hydrochloric acid, and the yield can be improved by optimizing reaction conditions such as temperature and concentration. The product is then purified by recrystallization from a suitable solvent.
About
CAS No
521284-19-5
English Name
(2R)-2-Hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide
Molecular Formula
C16H16N2O4
Molecular Weight
300.31 g/mol
SMILES
c1ccc(cc1)[C@H](C(=O)NCCc2ccc(cc2)[N+](=O)[O-])O
InChIKey
YWGDTDSOHPHFAQ-OAHLLOKOSA-N
Last Updated: 2025-10-08 00:58
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