(2-Chlorophenyl)(phenyl)methanone

Basic Information

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CAS Number

5162-03-8

Molecular Formula

C13H9ClO

Molecular Weight

216.67 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

44-47 °C

Boiling Point

330 °C

Refractive Index

1.5260 (estimate)

SMILES

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C1=CC=C(C=C1)C(=O)C2=CC=CC=C2Cl

InChI

InChI=1S/C13H9ClO/c14-12-9-5-4-8-11(12)13(15)10-6-2-1-3-7-10/h1-9H

InChIKey

VMHYWKBKHMYRNF-UHFFFAOYSA-N

LogP

3.5710000000000015

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

221

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

(2-Chlorophenyl)phenyl-methanone;2-Chlorobenzophenone
NSC-62529
NCIOpen2_002858
Q63395436
(2-Chloro-phenyl)-phenyl-methanone
2-Chlorobenzophenone
AC-10277
J-500719
Clotrimazole Impurity E
A854371
NS00015545
DTXSID6063721
(2-Chlorophenyl)phenylmethanone; Clotrimazole Imp. E (EP); 2-Chlorobenzophenone; Ph Eur Clotrimazole Impurity E; GW 300465X; Clotrimazole Impurity E
5162-03-8
Methanone, (2-chlorophenyl)phenyl-
(2-chlorophenyl)-phenylmethanone
SY037744
Clotrimazole impurity E, European Pharmacopoeia (EP) Reference Standard
2-Chlorobenyl phenyl ketone
2-Chlorobenzophenone, >=99%
MFCD00000558
AMY31909
DU8B664MRJ
(2-Chlorophenyl)phenylmethanone
AS-10885
Benzophenone, 2-chloro-
InChI=1/C13H9ClO/c14-12-9-5-4-8-11(12)13(15)10-6-2-1-3-7-10/h1-9H
Benzophenonchlorid
(2-Chlorophenyl)(phenyl)methanone
CS-W014830
CLOTRIMAZOLE IMPURITY E [EP IMPURITY]

MDL Number

MFCD00000558

Customs Code

2914700090

FAQ

What are the physical and chemical properties of (2-Chlorophenyl)(phenyl)methanone (CAS: 5162-03-8)?

(2-Chlorophenyl)(phenyl)methanone (CAS: 5162-03-8) is an organic compound with a molecular weight of approximately 211.17 g/mol. It is a white crystalline solid with a melting point around 78-80°C. The compound is slightly soluble in water but highly soluble in common organic solvents like ethanol and acetone. It exhibits moderate reactivity with nucleophiles and is used in various chemical reactions due to its functional groups. Its solubility and reactivity make it suitable for applications in pharmaceuticals and organic synthesis.

How is (2-Chlorophenyl)(phenyl)methanone (CAS: 5162-03-8) typically synthesized?

(2-Chlorophenyl)(phenyl)methanone (CAS: 5162-03-8) can be synthesized via the condensation reaction of 2-chloroacetophenone and phenylhydrazine. This reaction is typically carried out in the presence of a base like sodium hydroxide to facilitate the formation of the intermediate hydrazone, which then undergoes condensation. The yield is generally good, around 70-80%, and the method is suitable for both laboratory and industrial scale production.

What industries use (2-Chlorophenyl)(phenyl)methanone (CAS: 5162-03-8)?

(2-Chlorophenyl)(phenyl)methanone (CAS: 5162-03-8) is used in the pharmaceutical industry for the synthesis of various drug candidates due to its functional groups. It also finds applications in the polymer industry as a monomer for specific polymer synthesis. Additionally, it is used in the development of organic sensors and as a reagent in semiconductor manufacturing for the modification of surfaces. Its versatility makes it a valuable compound across multiple sectors.

What precautions should be taken when handling (2-Chlorophenyl)(phenyl)methanone (CAS: 5162-03-8)?

When handling (2-Chlorophenyl)(phenyl)methanone (CAS: 5162-03-8), it is crucial to follow standard laboratory safety guidelines. PPE such as gloves, goggles, and a lab coat should always be worn. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up immediately using appropriate absorbent materials and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures. This compound should be stored in a cool, dry place away from direct sunlight and sources of ignition.