(R)-Salbutamol HCl ((R)-Albuterol HCl)

Basic Information

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CAS Number

50293-90-8

Molecular Formula

C13H22ClNO3

Molecular Weight

275.78 g/mol

Chemical Classification

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

188-195°C

Boiling Point

433.5 °C at 760 mmHg

Flash Point

433.5 °C at 760 mmHg

Solubility

H2O: ≥15mg/mL

Specific Rotation

-25.0° - -35.0° (c=0.1, H2O)

SMILES

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CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O.Cl

InChI

InChI=1S/C13H21NO3.ClH/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;/h4-6,12,14-17H,7-8H2,1-3H3;1H/t12-;/m0./s1

InChIKey

OWNWYCOLFIFTLK-YDALLXLXSA-N

LogP

1.7277999999999998

Topological Polar Surface Area

72.72 Å²

Hydrogen Bond Donor/Acceptor

4 / 4

Complexity

227

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

EN300-1724220
148563-16-0
LEVALBUTEROL HYDROCHLORIDE (USP-RS)
Levalbuterol Inhalation Solution
Levalbuterol HCl
50293-90-8
AC-23919
ALBUTEROL (R)-FORM HYDROCHLORIDE [MI]
MFCD08067728
(R)-Salbutamol hydrochloride
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol hydrochloride
Zopenex (common misspelling of Xopenex)
LEVOSALBUTAMOL HYDROCHLORIDE (MART.)
(-)-Salbutamol hydrochloride
BCP04477
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol;hydrochloride
Levalbuterol hydrochloride (USP)
(R)-Albuterol Hydrochloride
F82066
1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, hydrochloride, (alpha1R)-
Levalbuterol hydrochloride [USAN]
Q27292577
Xopenex
1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Hydrochloride,(alpha1R)-
Levosalbutamol Hydrochloride
Hydrochloride, Levalbuterol
Zopenex [common misspelling of Xopenex]
LEVALBUTEROL HYDROCHLORIDE [USP-RS]
Xopenex (TN)
CCG-39986
UNII-WDQ1526QJM

MDL Number

MFCD08067728

FAQ

What are the physical and chemical properties of (R)-Salbutamol HCl (CAS: 50293-90-8)?

(R)-Salbutamol HCl (CAS: 50293-90-8) is a white crystalline powder with a molecular weight of approximately 251.71 g/mol. It is sparingly soluble in water and ethanol but soluble in organic solvents like methanol and dimethyl sulfoxide. Chemically, it is stable under normal conditions but can react with strong acids and bases. It is used as a bronchodilator in respiratory diseases.

How is (R)-Salbutamol HCl (CAS: 50293-90-8) typically synthesized?

(R)-Salbutamol HCl (CAS: 50293-90-8) is typically synthesized via asymmetric synthesis using a chiral auxiliary, such as (-)-menthol. The process involves a catalytic hydrogenation of a key intermediate, followed by hydrochloric acid addition to form the final product. The yield is usually around 70-80%, and the reaction is carried out under mild conditions to maintain the chirality.

What industries use (R)-Salbutamol HCl (CAS: 50293-90-8)?

(R)-Salbutamol HCl (CAS: 50293-90-8) is primarily used in the pharmaceutical industry to treat respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It is also used in polymer science for the synthesis of certain polymers and in the production of medical devices.

What precautions should be taken when handling (R)-Salbutamol HCl (CAS: 50293-90-8)?

When handling (R)-Salbutamol HCl (CAS: 50293-90-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves, lab coat, and eye protection. It should be stored under cool, dry conditions away from direct sunlight. In case of spill, it should be cleaned up immediately using appropriate absorbent material. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.