Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate

Basic Information

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CAS Number

439095-52-0

Molecular Formula

C14H20N2O2

Molecular Weight

248.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

37-44°C

Refractive Index

1.56

SMILES

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CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N

InChI

InChI=1S/C14H20N2O2/c1-2-18-14(17)11-7-9-16(10-8-11)13-5-3-12(15)4-6-13/h3-6,11H,2,7-10,15H2,1H3

InChIKey

JXCDVJXPSHIHLP-UHFFFAOYSA-N

LogP

2.0483000000000002

Topological Polar Surface Area

55.56 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

267

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

ETHYL1-(4-AMINOPHENYL)-4-PIPERIDINECARBOXYLATE
AM20061000
439095-52-0
SB43464
1-(4-amino-phenyl)-piperidine-4-carboxylic acid ethyl ester
SCHEMBL27543
FT-0680524
ethyl 1-(4-aminophenyl)piperidine-4-carboxylate
AC6147
Oprea1_613250
MFCD03425793
1-(4-Aminophenyl)-4-(ethoxycarbonyl)piperidine
J-520487
JXCDVJXPSHIHLP-UHFFFAOYSA-N
ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate
6T-0212
A848010
DTXSID20377342
CS-0452567
AKOS005070838
BCP20974
ethyl 1-(4-aminophenyl)piperidine-4-carboxylate;Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate
SY016490
Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate
4-Piperidinecarboxylicacid, 1-(4-aminophenyl)-, ethyl ester
4-(4-ethoxycarbonylpiperidino)aniline
WT695

MDL Number

MFCD03425793

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate (CAS: 439095-52-0)?

Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate is a white crystalline solid with a molecular weight of approximately 284.34 g/mol. It has a high solubility in organic solvents like methanol and ethanol but is only slightly soluble in water. The compound is moderately reactive and can undergo ester hydrolysis under basic conditions. It is stable under normal storage conditions but should be handled with care to avoid moisture exposure.

How is Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate (CAS: 439095-52-0) typically synthesized?

Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate is typically synthesized by a multistep process involving the condensation of ethyl 4-piperidinecarboxylate with 4-aminophenol. The synthesis often requires the use of a suitable catalyst, such as a base like sodium hydroxide, to promote the reaction. The yield is generally around 70-80%, and the method ensures good selectivity for the desired product.

What industries use Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate (CAS: 439095-52-0)?

Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the polymer industry for the modification of polymers to enhance their properties. Additionally, it has applications in the development of sensors and semiconductors due to its unique chemical structure and reactivity.

What precautions should be taken when handling Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate (CAS: 439095-52-0)?

When handling Ethyl 1-(4-aminophenyl)-4-piperidinecarboxylate, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to prevent inhalation. Spills should be immediately cleaned up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions. Storage should be in a cool, dry place away from heat sources and direct sunlight.