2-(Chloromethyl)quinoline

Basic Information

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CAS Number

4377-41-7

Molecular Formula

C10H8ClN

Molecular Weight

177.63 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

56.5-57.5 ºC

SMILES

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C1=CC=C2C(=C1)C=CC(=N2)CCl

InChI

InChI=1S/C10H8ClN/c11-7-9-6-5-8-3-1-2-4-10(8)12-9/h1-6H,7H2

InChIKey

DDEAEWMDOSXKBX-UHFFFAOYSA-N

LogP

2.97360

Complexity

149

Synonyms & References

English

2-Chloromethyl quinoline
2quinolinylmethylchloride
chloromethylquinoline
4377-41-7
EINECS 224-479-2
AM85771
2-(chloro methyl)quinoline
DDEAEWMDOSXKBX-UHFFFAOYSA-N
MFCD00023999
NSC158442
NSC 158442
2-Chloromethylquinoline
2-chloromethyiquinoline
AC-27318
2- (chloromethyl)quinoline
2-(CHLOROMETHYL)-QUINOLINE
NSC-158442
2-(chloromethyl) quinoline
2-(Chloromethyl)quinoline
AKOS015850529
BCP9000080
2-quinolinylmethylchloride
DTXSID70195932
BCP22822
s11826
NS00031365
2-chloro methyl quinoline
Quinoline, 2-(chloromethyl)-
2-Chloromethyquinoline
AB01399
2-chloromethyl quinolin

MDL Number

MFCD00023999

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 2-(Chloromethyl)quinoline (CAS: 4377-41-7)?

2-(Chloromethyl)quinoline (CAS: 4377-41-7) is a crystalline solid with a molecular weight of approximately 181.61 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. The compound is moderately reactive towards nucleophiles and can undergo nucleophilic substitution reactions. It is used in various applications requiring its unique chemical properties.

How is 2-(Chloromethyl)quinoline (CAS: 4377-41-7) typically synthesized?

2-(Chloromethyl)quinoline can be synthesized via the reaction of quinoline with chloroform in the presence of a Lewis acid catalyst, such as aluminum chloride. The process involves the formation of an intermediate that then undergoes substitution to yield the final product. The yield is generally around 70-80%, and the reaction is performed under anhydrous conditions to avoid hydrolysis.

What industries use 2-(Chloromethyl)quinoline (CAS: 4377-41-7)?

2-(Chloromethyl)quinoline (CAS: 4377-41-7) is used in the pharmaceutical industry for the development of certain medicinals. It is also utilized in the polymer industry for the production of specialized polymers, and in the sensor and semiconductor industries for specific chemical sensing applications.

What precautions should be taken when handling 2-(Chloromethyl)quinoline (CAS: 4377-41-7)?

When handling 2-(Chloromethyl)quinoline (CAS: 4377-41-7), appropriate personal protective equipment (PPE) should be used, including gloves, goggles, and a lab coat. The compound should be worked with in a well-ventilated area, preferably a fume hood, to avoid inhalation. Spills should be cleaned up carefully, and the material safety data sheet (MSDS) should be consulted for detailed spill procedures. Proper disposal methods should be followed according to local regulations.