Compound Q&A

How is 2-(Chloromethyl)quinoline (CAS: 4377-41-7) typically synthesized?

Answer

2-(Chloromethyl)quinoline
2-(Chloromethyl)quinoline can be synthesized via the reaction of quinoline with chloroform in the presence of a Lewis acid catalyst, such as aluminum chloride. The process involves the formation of an intermediate that then undergoes substitution to yield the final product. The yield is generally around 70-80%, and the reaction is performed under anhydrous conditions to avoid hydrolysis.

About

CAS No 4377-41-7
English Name 2-(Chloromethyl)quinoline
Molecular Formula C10H8ClN
Molecular Weight 177.63 g/mol
SMILES C1=CC=C2C(=C1)C=CC(=N2)CCl
InChIKey DDEAEWMDOSXKBX-UHFFFAOYSA-N
Last Updated: 2026-01-01 15:35

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