4-[6-(4-Hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol

Basic Information

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CAS Number

4263-88-1

Molecular Formula

C20H22O6

Molecular Weight

358.39 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Powder

Melting Point

144-145 ºC

SMILES

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COC1=C(C=CC(=C1)C2C3COC(C3CO2)C4=CC(=C(C=C4)O)OC)O

InChI

InChI=1S/C20H22O6/c1-23-17-7-11(3-5-15(17)21)19-13-9-26-20(14(13)10-25-19)12-4-6-16(22)18(8-12)24-2/h3-8,13-14,19-22H,9-10H2,1-2H3

InChIKey

HGXBRUKMWQGOIE-UHFFFAOYSA-N

LogP

3.190200000000002

Topological Polar Surface Area

77.38000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

431

Safety Information

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Storage Conditions

2-8℃

Synonyms & References

English

(±)-Pinoresinol
Pinoresinol
(+/-)-Pinoresinol
pinoresinol monomethyl ether
4-[(3S,3aR,6S,6aR)-6-(4-hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol
4263-88-1
SCHEMBL122106
4,4'-[(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2-methoxyphenol)
CHEMBL2252392
H1692
4-[6-(4-hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol
Phenol,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2-methoxy-, [1S-(1.alpha.,3a.alpha.,4.alpha.,6a.alpha.)]-
4,4'-(Hexahydrofuro[3,4-c]furan-1,4-diyl)bis(2-methoxyphenol)
7452-03-1
B0005-188759
NSC35444
4,4'-[Hexahydrofuro[3,4-c]furan-1,4-diyl]bis(2-methoxyphenol)
(+/-)-PINORESINOL
HMS3347E17
D91065
bmse010297
(+)-Pinoresinol, 4,4'-((1S,3aR,4S,6aR)-Hexahydrofuro[3,4-c]furan-1,4-diyl)bis(2-methoxyphenol)

MDL Number

MFCD31557157

FAQ

What are the physical and chemical properties of 4-[6-(4-Hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol (CAS: 4263-88-1)?

4-[6-(4-Hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol is a crystalline solid with a molecular weight of approximately 427.45 g/mol. It has a pKa of around 9.0 and is slightly soluble in water. The compound is reactive towards nucleophiles and can undergo esterification and etherification reactions. It is also prone to oxidation under certain conditions.

How is 4-[6-(4-Hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol (CAS: 4263-88-1) typically synthesized?

This compound can be synthesized via a multi-step process involving the condensation of 3-methoxy-4-hydroxybenzaldehyde with 6-(3-methoxy-4-hydroxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan. The synthesis typically requires the use of a strong base such as sodium hydride and needs to be conducted in an inert atmosphere to prevent side reactions. Careful control of reaction conditions is necessary to achieve high yields and selectivity.

What industries use 4-[6-(4-Hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol (CAS: 4263-88-1)?

4-[6-(4-Hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol is primarily used in the pharmaceutical and chemical industries. It serves as a precursor for the synthesis of various drug compounds and is also used in the development of new materials and sensors. Its unique chemical properties make it suitable for applications in semiconductors and other advanced materials.

What precautions should be taken when handling 4-[6-(4-Hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol (CAS: 4263-88-1)?

When handling 4-[6-(4-Hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a laboratory coat. The substance should be handled in a fume hood to minimize exposure to air and avoid inhalation. Proper spill cleanup procedures should be followed, and the material safety data sheet (MSDS) should be consulted for specific guidelines. Storage should be in a cool, dry place away from direct sunlight and heat sources.