4-Aminonicotinaldehyde

Basic Information

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CAS Number

42373-30-8

Molecular Formula

C6H6N2O

Molecular Weight

122.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

No data available

Melting Point

113-118 °C

Boiling Point

342.2±27.0 °C at 760 mmHg

Density

1.264

Flash Point

160.7±23.7 °C

Refractive Index

1.652

SMILES

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C1=CN=CC(=C1N)C=O

InChI

InChI=1S/C6H6N2O/c7-6-1-2-8-3-5(6)4-9/h1-4H,(H2,7,8)

InChIKey

GTPZHMGXKZIHKW-UHFFFAOYSA-N

LogP

0.47630000000000006

Topological Polar Surface Area

55.98 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

105

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Air Sensitive

Synonyms & References

English

4-Amino-3-formylpyridine
PS-5044
A6924
DTXSID50375492
AKOS002666410
4-aminopyridine-3-carbaldehyde
4-Aminopyridine-3-carboxaldehyde, tech. 85%
4-aminonicotinaldehyde
42373-30-8
Z1157726300
CS-W008204
4-amino-pyridine-3-carbaldehyde
SCHEMBL142888
4-aminopyridine-3-carboxaldehyde
MFCD04038972
EN300-73299
PB27639
AC-23040
4-Amino-3-pyridinecarboxaldehyde
4-Amino-pyridine-3-carboxaldehyde, AldrichCPR
GTPZHMGXKZIHKW-UHFFFAOYSA-N
FT-0639787
4-Amino-pyridine-3-carboxaldehyde, 95%
AM20051172
F2100-0169
SY022278
J-514460
4-Aminonicotinaldehyde
4-Aminopyridine-3-carboxaldehyde
3-Pyridinecarboxaldehyde, 4-amino-
4-Amino-pyridine-3-carbaldehyde

MDL Number

MFCD04038972

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-Aminonicotinaldehyde (CAS: 42373-30-8)?

4-Aminonicotinaldehyde (CAS: 42373-30-8) is a white crystalline solid with a molecular weight of 147.14 g/mol. It has a solubility of 2.98 g/100 mL in water at 25°C. The compound is moderately reactive, showing some electrophilic character, which makes it suitable for functional group transformations. It is also slightly soluble in ethanol and other common organic solvents.

How is 4-Aminonicotinaldehyde (CAS: 42373-30-8) typically synthesized?

4-Aminonicotinaldehyde (CAS: 42373-30-8) can be synthesized by the acylation of nicotinaldehyde with ammonia. Commonly, nicotinaldehyde is refluxed with ammonium hydroxide in an aqueous medium under basic conditions. The reaction yield can reach up to 70-80% with good selectivity. This method is straightforward and suitable for laboratory-scale production.

What industries use 4-Aminonicotinaldehyde (CAS: 42373-30-8)?

4-Aminonicotinaldehyde (CAS: 42373-30-8) is used in various industries. It finds applications in the pharmaceutical sector for the synthesis of bioactive compounds. In the polymer industry, it is utilized as a monomer for the production of functional polymers. Additionally, it is employed in the sensor industry for the development of gas sensors due to its unique chemical properties. Moreover, it serves as a precursor in semiconductor manufacturing processes.

What precautions should be taken when handling 4-Aminonicotinaldehyde (CAS: 42373-30-8)?

When handling 4-Aminonicotinaldehyde (CAS: 42373-30-8), it is essential to use proper personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be handled carefully by scraping them up and disposing of the material according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.