4-Aminonicotinaldehyde(CAS: 42373-30-8)

4-Aminonicotinaldehyde (CAS: 42373-30-8) is a white crystalline solid with a molecular weight of 147.14 g/mol. It has a solubility of 2.98 g/100 mL in water at 25°C. The compound is moderately reactive, showing some electrophilic character, which makes it suitable for functional group transformations. It is also slightly soluble in ethanol and other common organic solvents.

4-Aminonicotinaldehyde (CAS: 42373-30-8) can be synthesized by the acylation of nicotinaldehyde with ammonia. Commonly, nicotinaldehyde is refluxed with ammonium hydroxide in an aqueous medium under basic conditions. The reaction yield can reach up to 70-80% with good selectivity. This method is straightforward and suitable for laboratory-scale production.

4-Aminonicotinaldehyde (CAS: 42373-30-8) is used in various industries. It finds applications in the pharmaceutical sector for the synthesis of bioactive compounds. In the polymer industry, it is utilized as a monomer for the production of functional polymers. Additionally, it is employed in the sensor industry for the development of gas sensors due to its unique chemical properties. Moreover, it serves as a precursor in semiconductor manufacturing processes.

When handling 4-Aminonicotinaldehyde (CAS: 42373-30-8), it is essential to use proper personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be handled carefully by scraping them up and disposing of the material according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.