3-nitropyridin-2-amine

Basic Information

View in Editor

CAS Number

4214-75-9

Molecular Formula

C5H5N3O2

Molecular Weight

139.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

164.0 to 168.0 deg-C

Boiling Point

299.1°C at 760 mmHg

Solubility

3g/l

Refractive Index

1.5900 (estimate)

SMILES

View in Editor

C1=CC(=C(N=C1)N)[N+](=O)[O-]

InChI

InChI=1S/C5H5N3O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H,(H2,6,7)

InChIKey

BPYHGTCRXDWOIQ-UHFFFAOYSA-N

LogP

1.67640

Complexity

133

Safety Information

View Safety Information

GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

PB19852
NSC 12460
3-Nitro-2-amino pyridine
2-Amino-3-nitropyridine, 99%
EINECS 224-144-0
A6893
2-Amino-3-nitropyridine
FT-0611069
2-Pyridinamine, 3-nitro-
2-amino3-nitropyridine
4214-75-9
AM20070073
3-nitropyridin-2-amine
2-amino-3-nitro-pyridine
A0838
AC-24962
NSC-12460
BCP22102
UNII-U52GH47YQX
DTXSID40194977
Pyridine, 2-amino-3-nitro-
SCHEMBL17802800
U52GH47YQX
SCHEMBL57910
JBE
HY-59237
InChI=1/C5H5N3O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H,(H2,6,7
NS00031110
3-Nitropyridin-2-ylamine
MFCD00006314
AS-11574

MDL Number

MFCD00006314

Customs Code

29333999

FAQ

What are the physical and chemical properties of 3-nitropyridin-2-amine (CAS: 4214-75-9)?

3-nitropyridin-2-amine (CAS: 4214-75-9) is a crystalline compound with a molecular weight of approximately 155.08 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetonitrile. The compound is known for its stability but can react with strong acids and bases. It has a pKa of around 5.7, indicating moderate basicity.

How is 3-nitropyridin-2-amine (CAS: 4214-75-9) typically synthesized?

3-nitropyridin-2-amine can be synthesized via a multi-step process. Common methods include the reduction of 3-nitropyridine with a suitable reducing agent such as sodium borohydride. The overall reaction involves the formation of the amine from the nitro group, and the process typically achieves a yield of around 70-80%. Catalysts such as palladium on carbon can be used to improve the efficiency of the reduction.

What industries use 3-nitropyridin-2-amine (CAS: 4214-75-9)?

3-nitropyridin-2-amine (CAS: 4214-75-9) finds applications in various industries. It is used in pharmaceuticals for the synthesis of certain drugs, particularly in the development of anticancer and anti-inflammatory agents. It is also used in the polymer industry for the modification of polymers to improve their properties. Additionally, it has applications in the sensor and semiconductor industries due to its reactive functional groups.

What precautions should be taken when handling 3-nitropyridin-2-amine (CAS: 4214-75-9)?

When handling 3-nitropyridin-2-amine (CAS: 4214-75-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from sources of heat and ignition. It should be used in a fume hood to minimize exposure. In case of spillage, it should be cleaned up using absorbent materials and disposed of in accordance with local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.