Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH | CAS No. 41961-56-2

Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH

Basic Information

CAS Number

41961-56-2

Molecular Formula

C15H28N4O5

Molecular Weight

344.41 g/mol

AD

Basic Physical Properties

CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)O)N)O

InChI

InChI=1S/C15H28N4O5/c1-9(20)12(17)13(21)18-10(5-2-3-7-16)14(22)19-8-4-6-11(19)15(23)24/h9-12,20H,2-8,16-17H2,1H3,(H,18,21)(H,23,24)/t9-,10+,11+,12+/m1/s1

InChIKey

WFAUDCSNCWJJAA-RHYQMDGZSA-N

LogP

0.11330

Complexity

459

Synonyms & References

English

  • SCHEMBL8760024
  • 41961-56-2
  • MACROPHAGE INHIBITORY PEPTIDE
  • (S)-1-((S)-6-Amino-2-((2S,3R)-2-amino-3-hydroxybutanamido)hexanoyl)pyrrolidine-2-carboxylic acid
  • (2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
  • Threonyl-lysyl-proline
  • DTXSID20962116
  • N~2~-(2-Amino-1,3-dihydroxybutylidene)lysylproline
  • L-Proline, 1-(N2-L-threonyl-L-lysyl)-
  • H-Thr-Lys-Pro-OH
  • L-Proline,L-threonyl-L-lysyl-
  • H-THR-LYS-PRO-OH
  • Macrophage Inhibitory Peptide
  • THR-LYS-PRO
  • Tuftsin (1-3), Macrophage Inhibitory Peptide
  • threonyl-lysyl-proline
  • Tuftsin (1-3)
  • Tuftsin Fragment1-3 monohydrate acetate salt
  • (Des-Arg4)-tuftsin

MDL Number

MFCD00076864

FAQ

What are the physical and chemical properties of Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH (CAS: 41961-56-2)?

Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH is a peptide with a molecular weight of approximately 599.44 Da. It has limited solubility in water and organic solvents. This peptide is relatively stable under normal conditions but may degrade under acidic or basic conditions. It is typically crystalline in form and can be characterized by its specific UV absorption spectrum and mass spectrometry analysis.

How is Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH (CAS: 41961-56-2) typically synthesized?

Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH is synthesized through solid-phase peptide synthesis (SPPS) using Fmoc chemistry. The key steps include coupling of amino acids, cleavage from the resin, and deprotection. Commonly, t-Boc protection is used for threonine and lysine residues, and the final product is obtained with a yield of around 70-80%.

What industries use Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH (CAS: 41961-56-2)?

Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH (CAS: 41961-56-2) is primarily used in the pharmaceutical industry for research purposes, including the development of anti-inflammatory drugs. It is also used in biotechnology for studying immune response and in sensor technology for detecting immune cell activity.

What precautions should be taken when handling Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH (CAS: 41961-56-2)?

When handling Macrophage Inhibitory Peptide H-Thr-Lys-Pro-OH (CAS: 41961-56-2), it is advised to use personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. Work should be conducted in a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.

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