1-(2,3-Dichlorophenyl)piperazine

Basic Information

View in Editor

CAS Number

41202-77-1

Molecular Formula

C10H12Cl2N2

Molecular Weight

231.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

242-244°C

Boiling Point

127℃/0.8mmHg

Flash Point

174.6℃

SMILES

View in Editor

C1CN(CCN1)C2=C(C(=CC=C2)Cl)Cl

InChI

InChI=1S/C10H12Cl2N2/c11-8-2-1-3-9(10(8)12)14-6-4-13-5-7-14/h1-3,13H,4-7H2

InChIKey

UDQMXYJSNNCRAS-UHFFFAOYSA-N

LogP

2.4030000000000005

Topological Polar Surface Area

15.27 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

183

Safety Information

View Safety Information

Hazard Statement

Synonyms & References

English

BDBM50394930
AC-328
2,3 dichlorophenyl piperazine
1-(2,3-dichlorophenyl)piperazine
MFCD01075181
HMS2415O17
MLS000550163
UDQMXYJSNNCRAS-UHFFFAOYSA-N
N-(2,3-Dichlorophenyl)piperazine
AM20090770
(2,3-Dichlorophenyl)piperazine
4-(2,3-dichlorophenyl)piperazine
UNII-891W3EV0B1
2,3-Dichlorophenylpiperazine
PD047502
Q4596761
CHEMBL1424807
1-(2,3-dichlorphenyl)-piperazine
1-(2 pound not3-Dichlorophenyl)piperazine
2,3-Dichlorophenyl piperazine
AQ-360/42118436
41202-77-1
891W3EV0B1
SMR000115758
SCHEMBL8511
A6839
FT-0605474
NS00002643
ARIPIPRAZOLE IMPURITY B [EP IMPURITY]
Piperazine, 1-(2,3-dichlorophenyl)-
EN300-1966560

MDL Number

MFCD01075181

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 1-(2,3-Dichlorophenyl)piperazine (CAS: 41202-77-1)?

1-(2,3-Dichlorophenyl)piperazine is a white crystalline solid with a molecular weight of 274.03 g/mol. Its solubility is 2.3 g/L in water, 30 g/L in ethanol, and 15 g/L in acetone. It is slightly reactive and susceptible to hydrolysis under acidic conditions. The compound is stable under normal storage conditions but should be protected from moisture and light.

How is 1-(2,3-Dichlorophenyl)piperazine (CAS: 41202-77-1) typically synthesized?

1-(2,3-Dichlorophenyl)piperazine can be synthesized using amination of 2,3-dichlorophenyl isocyanate with piperazine. The synthesis involves the use of a mild base like triethylamine and is conducted in anhydrous conditions. The reaction yields 85-90% of the product with good selectivity.

What industries use 1-(2,3-Dichlorophenyl)piperazine (CAS: 41202-77-1)?

1-(2,3-Dichlorophenyl)piperazine is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry for the production of specialty polymers. Additionally, it has applications in sensors and semiconductors due to its unique physical and chemical properties.

What precautions should be taken when handling 1-(2,3-Dichlorophenyl)piperazine (CAS: 41202-77-1)?

When handling 1-(2,3-Dichlorophenyl)piperazine, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be used. The compound should be stored in a cool, dry place away from moisture and light. Fume hoods should be used during handling to minimize inhalation risk. In case of a spill, the area should be flushed with water and appropriate cleanup procedures should be followed. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and safety measures.