6-Fluoronicotinic acid

Basic Information

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CAS Number

403-45-2

Molecular Formula

C6H4FNO2

Molecular Weight

141.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

147°C(dec.)

Boiling Point

309.4℃ at 760 mmHg

Density

1.419

Flash Point

140.9℃

SMILES

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C1=CC(=NC=C1C(=O)O)F

InChI

InChI=1S/C6H4FNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H,9,10)

InChIKey

UJDLCTNVHJEBDG-UHFFFAOYSA-N

LogP

0.9189

Topological Polar Surface Area

50.19 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

140

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

6-Fluoropyridine-3-carboxylic acid, 97%
6-fluoro-3-pyridinecarboxylic acid
2-fluoropyridine-5-carboxylic acid
FT-0600911
2-Fluoro-5-pyridinecarboxylic Acid
PS-9025
DTXSID80287610
SCHEMBL646556
6-fluoro nicotinic acid
Z1182395505
J-400794
AKOS005254427
F0695
6-Fluoropyridine-3-carboxylic acid
6-fluoro-pyridine-3-carboxylic acid
MFCD01859863
AM20051164
CS-W019722
6-Fluoronicotinic acid
2-Fluoro-5-pyridine carboxylic acid
NSC51767
6-Fluoronicotinicacid
AB09999
2-fluoro-pyridine-5-carboxylic acid
UJDLCTNVHJEBDG-UHFFFAOYSA-N
403-45-2
EN300-75668
NSC-51767
6-fluoropyridine-3-formic acid
AC-18825
SY004391

MDL Number

MFCD01859863

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 6-Fluoronicotinic acid (CAS: 403-45-2)?

6-Fluoronicotinic acid is a white crystalline solid with a molecular weight of 142.01 g/mol. It is slightly soluble in water and ethanol. Chemically, it is an acidic compound, reacting readily with bases and forming salts. Its reactivity and solubility vary with different solvents and conditions.

How is 6-Fluoronicotinic acid (CAS: 403-45-2) typically synthesized?

6-Fluoronicotinic acid is typically synthesized by fluorination of nicotinic acid using reagents like sulfuryl fluoride or trifluoroacetic anhydride. The process involves selective fluorination under controlled conditions, with yields ranging from 70% to 90% depending on the method and purity of starting materials.

What industries use 6-Fluoronicotinic acid (CAS: 403-45-2)?

6-Fluoronicotinic acid is used in pharmaceuticals for the synthesis of medicinal compounds, in polymers for the production of advanced materials, and in sensors for detecting specific chemical species. It also finds applications in semiconductor manufacturing for etching processes.

What precautions should be taken when handling 6-Fluoronicotinic acid (CAS: 403-45-2)?

When handling 6-Fluoronicotinic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be handled with care using appropriate absorbents, and the incident should be documented and reported as per safety protocols. Always refer to the Safety Data Sheet (SDS) for detailed safety information.