6-Fluoronicotinic acid(CAS: 403-45-2)

6-Fluoronicotinic acid is a white crystalline solid with a molecular weight of 142.01 g/mol. It is slightly soluble in water and ethanol. Chemically, it is an acidic compound, reacting readily with bases and forming salts. Its reactivity and solubility vary with different solvents and conditions.

6-Fluoronicotinic acid is typically synthesized by fluorination of nicotinic acid using reagents like sulfuryl fluoride or trifluoroacetic anhydride. The process involves selective fluorination under controlled conditions, with yields ranging from 70% to 90% depending on the method and purity of starting materials.

6-Fluoronicotinic acid is used in pharmaceuticals for the synthesis of medicinal compounds, in polymers for the production of advanced materials, and in sensors for detecting specific chemical species. It also finds applications in semiconductor manufacturing for etching processes.

When handling 6-Fluoronicotinic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be handled with care using appropriate absorbents, and the incident should be documented and reported as per safety protocols. Always refer to the Safety Data Sheet (SDS) for detailed safety information.