2-Amino-1,3-thiazole-5-carboxylic acid

Basic Information

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CAS Number

40283-46-3

Molecular Formula

C4H4N2O2S

Molecular Weight

144.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

196-202°C

Boiling Point

415°C at 760 mmHg

Flash Point

204.8℃

SMILES

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C1=C(SC(=N1)N)C(=O)O

InChI

InChI=1S/C4H4N2O2S/c5-4-6-1-2(9-4)3(7)8/h1H,(H2,5,6)(H,7,8)

InChIKey

ZFMRDDYYJJCBKC-UHFFFAOYSA-N

LogP

0.42350000000000004

Topological Polar Surface Area

76.21 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

130

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

aminothiazole 5-carboxylic acid
A825032
40283-46-3
NSC-239729
AM20100074
2-amino-1,3-thiazole-5-carboxylic acid
ZFMRDDYYJJCBKC-UHFFFAOYSA-N
2-amino-5-thiazolecarboxylic acid
EN300-106106
PS-6203
AB23200
J-508082
CS-W003268
SCHEMBL1631557
2-Aminothiazole-5-carboxylic acid
SY003801
MFCD06203554
AC-3089
AKOS010056916
NSC239729
2-aminothiazole-5-carboxylic acid, AldrichCPR
2-Aminothiazole-5-carboxylicAcid
NSC 239729
DTXSID30311171
FT-0647745
5-Thiazolecarboxylic acid, 2-amino-
2-Amino-1,3-thiazole-5-carboxylic Acid
2-aminothiazole-5-formic acid
PubChem21384
5-Thiazolecarboxylicacid, 2-amino-
SBB066572

MDL Number

MFCD06203554

FAQ

What are the physical and chemical properties of 2-Amino-1,3-thiazole-5-carboxylic acid (CAS: 40283-46-3)?

2-Amino-1,3-thiazole-5-carboxylic acid (CAS: 40283-46-3) is a solid with a white or off-white crystalline form. Its molecular weight is approximately 154.19 g/mol. It is slightly soluble in water and has good solubility in organic solvents like acetone and dimethylformamide. Chemically, it is reactive towards nucleophiles and can participate in condensation reactions. It is also known for its ability to form hydrogen bonds.

How is 2-Amino-1,3-thiazole-5-carboxylic acid (CAS: 40283-46-3) typically synthesized?

2-Amino-1,3-thiazole-5-carboxylic acid can be synthesized by reacting thioacetic acid with hydrazine hydrate, followed by acylation of the hydrazide with an appropriate carboxylic acid chloride. This process involves the formation of a thiazolidine-2,4-dione intermediate, which then cyclizes to the final product. The reaction typically proceeds with good yield and selectivity.

What industries use 2-Amino-1,3-thiazole-5-carboxylic acid (CAS: 40283-46-3)?

2-Amino-1,3-thiazole-5-carboxylic acid finds applications in various industries. It is used in the pharmaceutical sector for the synthesis of antibiotics and antifungal agents. In the polymer industry, it serves as a precursor for the production of functionalized polymers. It also finds applications in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 2-Amino-1,3-thiazole-5-carboxylic acid (CAS: 40283-46-3)?

When handling 2-Amino-1,3-thiazole-5-carboxylic acid (CAS: 40283-46-3), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up using an appropriate absorbent material and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.