4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid

Basic Information

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CAS Number

39091-01-5

Molecular Formula

C10H8N2O2S

Molecular Weight

220.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

244-248 °C (dec.)

Boiling Point

459 °C at 760 mmHg

Density

1.381

Flash Point

231.4 °C

SMILES

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CC1=C(SC(=N1)C2=CN=CC=C2)C(=O)O

InChI

InChI=1S/C10H8N2O2S/c1-6-8(10(13)14)15-9(12-6)7-3-2-4-11-5-7/h2-5H,1H3,(H,13,14)

InChIKey

CJLQNROYBZEUGH-UHFFFAOYSA-N

LogP

2.2117199999999997

Topological Polar Surface Area

63.08 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

250

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SY204633
2-(3-Pyridyl)-4-methylthiazole-5-carboxylic acid
VU0609741-1
4-Methyl-2-(3-pyridinyl)-5-thiazolecarboxylic acid
4-methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylic acid
AM20051137
4-methyl-2-(pyridin-3-yl)thiazole-5-carboxylic acid
MFCD00171753
4-methyl-2-(pyridin-3-yl)thiazole-5-carboxylicacid
BCP27280
4-Methyl-2-pyridin-3-yl-thiazole-5-carboxylicacid
Z274740234
4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLICACID
SCHEMBL595294
2-(3-Pyridyl)-4-methylthiazole-5-carboxylic acid, 97%
4-Methyl-2-(3-Pyridyl)-5-Thiazolecarboxylic Acid
A6559
FT-0630050
4-methyl-2-pyridin-3-yl-1,3-thiazole-5-carboxylic acid
4-methyl-2-(3-pyridyl)-1,3-thiazole-5-carboxylic acid
BB 0238578
4-Methyl-2-(3-Pyridinyl)-1,3-Thiazole-5-Carboxylic Acid
DTXSID50376984
39091-01-5
CS-W013144
F3308-4057
Q-102477
1G-380S
4-Methyl-2-(3-pyridyl)thiazole-5-carboxylic acid
4-Methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid
4-methyl-2-(pyrid-3-yl)thiazole-5-carboxylic acid

MDL Number

MFCD00171753

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid (CAS: 39091-01-5)?

4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid has a crystalline form and a molecular weight of approximately 269.26 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is known for its reactivity with nucleophiles and its acidic nature due to the carboxylic acid group.

How is 4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid (CAS: 39091-01-5) typically synthesized?

This compound is usually synthesized by the condensation of 4-methyl-2-(3-pyridinyl)-1,3-thiazole with acetic anhydride, followed by hydrolysis. Commonly used catalysts include sulfuric acid, and the yield is typically around 70-80%. The reaction is exothermic and should be carried out in an inert atmosphere to prevent side reactions.

What industries use 4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid (CAS: 39091-01-5)?

4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid is primarily used in the pharmaceutical industry as an intermediate for drug synthesis. It is also found in polymer and sensor applications, where its unique chemical properties make it suitable for these specialized industries.

What precautions should be taken when handling 4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid (CAS: 39091-01-5)?

When handling 4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid, safety goggles and gloves should be worn, and the material should be used in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents as per the Safety Data Sheet (SDS). Storage should be in a cool, dry place away from direct sunlight and heat sources. Refer to the SDS for detailed safety information.