4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid(CAS: 39091-01-5)

4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid has a crystalline form and a molecular weight of approximately 269.26 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is known for its reactivity with nucleophiles and its acidic nature due to the carboxylic acid group.

This compound is usually synthesized by the condensation of 4-methyl-2-(3-pyridinyl)-1,3-thiazole with acetic anhydride, followed by hydrolysis. Commonly used catalysts include sulfuric acid, and the yield is typically around 70-80%. The reaction is exothermic and should be carried out in an inert atmosphere to prevent side reactions.

4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid is primarily used in the pharmaceutical industry as an intermediate for drug synthesis. It is also found in polymer and sensor applications, where its unique chemical properties make it suitable for these specialized industries.

When handling 4-Methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylic acid, safety goggles and gloves should be worn, and the material should be used in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents as per the Safety Data Sheet (SDS). Storage should be in a cool, dry place away from direct sunlight and heat sources. Refer to the SDS for detailed safety information.