8-Quinolinecarbaldehyde

Basic Information

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CAS Number

38707-70-9

Molecular Formula

C10H7NO

Molecular Weight

157.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

92.0 to 97.0 deg-C

Boiling Point

314.3°C at 760 mmHg

Density

1.223

Water Solubility

Insoluble in water.

Flash Point

151.9°C

Refractive Index

1.687

SMILES

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C1=CC2=C(C(=C1)C=O)N=CC=C2

InChI

InChI=1S/C10H7NO/c12-7-9-4-1-3-8-5-2-6-11-10(8)9/h1-7H

InChIKey

OVZQVGZERAFSPI-UHFFFAOYSA-N

LogP

2.0473

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

169

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Air Sensitive

Synonyms & References

English

SCHEMBL194281
8-Formylquinoline
BCP26541
4XS4PNS258
Q0096
BB 0221204
38707-70-9
FT-0600498
8-Quinolinecarbaldehyde, AldrichCPR
NS00124221
Z203978048
A6533
DTXSID10192001
SB67459
Quinoline-8-carboxaldehyde
UNII-4XS4PNS258
PS-4258
OVZQVGZERAFSPI-UHFFFAOYSA-N
quinoline-8-carbaldehyde
F0178-0024
CCRIS 6968
AM803824
QUINOLINE-8-CARBALDEHYD
AKOS000264863
CS-B1077
8-Quinolinecarboaldehyde
8-Quinolinecarboxaldehyde
MFCD00805837
AC-2609
EN300-26715
4122-88-7

MDL Number

MFCD00805837

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 8-Quinolinecarbaldehyde (CAS: 38707-70-9)?

8-Quinolinecarbaldehyde (CAS: 38707-70-9) is a yellow solid with a molecular weight of approximately 169.17 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. It is moderately reactive and susceptible to hydrolysis under basic conditions. This compound is known for its ability to form complexes with various metal ions and exhibits significant electrophilic aromatic substitution reactivity.

How is 8-Quinolinecarbaldehyde (CAS: 38707-70-9) typically synthesized?

8-Quinolinecarbaldehyde can be synthesized via the reduction of 8-quinolinecarboxylic acid using sodium borohydride or similar reducing agents. Another method involves the alkylation of 8-quinolone with formaldehyde followed by hydrolysis. The reaction conditions, such as temperature and catalysts, can vary, but the overall yield is typically around 70-80%. This compound is also prepared through condensation reactions involving quinoline derivatives and aldehydes.

What industries use 8-Quinolinecarbaldehyde (CAS: 38707-70-9)?

8-Quinolinecarbaldehyde (CAS: 38707-70-9) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring specific substituents on quinoline rings. It is also employed in the polymer industry to improve the properties of certain polymers. Additionally, this compound has applications in the development of sensors and semiconductors due to its unique optical and electronic properties.

What precautions should be taken when handling 8-Quinolinecarbaldehyde (CAS: 38707-70-9)?

When handling 8-Quinolinecarbaldehyde (CAS: 38707-70-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation exposure. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions. Given its reactivity, it should be stored in a cool, dry place away from direct sunlight and heat sources.