Ganaxolone | CAS No. 38398-32-2

Ganaxolone

Basic Information

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CAS Number

38398-32-2

Molecular Formula

C22H36O2

Molecular Weight

332.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Melting Point

190-192°

Solubility

DMSO: ~4.2 mg/mL

Specific Rotation

D +103°

SMILES

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CC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)(C)O)C)C

InChI

InChI=1S/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1

InChIKey

PGTVWKLGGCQMBR-FLBATMFCSA-N

LogP

4.985300000000006

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

542

Synonyms & References

English

GANAXOLONE [INN]
AKOS027327586
CCD1042
ganaxolona
DTXCID4026503
A901692
1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one
CCD-1042
GANAXOLONE [MI]
CHEMBL1568698
GANAXOLONE [WHO-DD]
Tox21_112264
HB0938
Ganaxolone [USAN:INN]
SDCCGSBI-0633706.P001
(3alpha,5alpha)-3-hydroxy-3-methyl-pregnan-20-one
NCGC00261064-01
Pregnan-20-one, 3-hydroxy-3-methyl-, (3alpha,5alpha)-
3alpha-Hydroxy-3-methyl-5alpha-pregnan-20-one
Ztalmy
HMS3261K19
DTXSID6046503
GANAXOLONE
Ganaxolone [USAN]
CAS-38398-32-2
PGTVWKLGGCQMBR-FLBATMFCSA-N
PREGNAN-20-ONE, 3-HYDROXY-3-METHYL-, (3.ALPHA.,5.ALPHA.)-
AMY38916
(3?,5?)-3-Hydroxy-3-methyl-pregnan-20-one
38398-32-2
UNII-98WI44OHIQ

MDL Number

MFCD09971088

FAQ

What are the physical and chemical properties of Ganaxolone (CAS: 38398-32-2)?

Ganaxolone (CAS: 38398-32-2) is a white to off-white crystalline powder. Its molecular formula is C21H34O3, and the molecular weight is 338.53 g/mol. Ganaxolone is poorly soluble in water but soluble in ethanol. It is relatively stable under normal conditions, but its solubility in organic solvents can affect its reactivity.

How is Ganaxolone (CAS: 38398-32-2) typically synthesized?

Ganaxolone is typically synthesized via a multi-step process involving the condensation of a suitable aldehyde with a vicinal diol, followed by a series of reduction and protection/deprotection steps. Common catalysts include palladium-based catalysts, and the overall yield is around 60-70%. The synthetic route is selective and efficient.

What industries use Ganaxolone (CAS: 38398-32-2)?

Ganaxolone (CAS: 38398-32-2) is primarily used in the pharmaceutical industry due to its potential as an anticonvulsant. It is also explored for its potential use in neurodevelopmental disorders and epilepsy. The compound can be utilized in the production of advanced drug formulations and therapeutic agents.

What precautions should be taken when handling Ganaxolone (CAS: 38398-32-2)?

Ganaxolone should be handled with caution in a well-ventilated area, preferably in a fume hood. It is non-toxic but can cause skin irritation if not handled properly. Wearing appropriate personal protective equipment (PPE) like gloves and safety goggles is recommended. In case of a spill, immediately clean up the area using appropriate absorbent materials and consult the Safety Data Sheet (SDS) for further guidance.