2,4-Difluorobiphenyl

Basic Information

View in Editor

CAS Number

37847-52-2

Molecular Formula

C12H8F2

Molecular Weight

190.19 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

61.0 to 65.0 deg-C

Boiling Point

243.7 °C at 760 mmHg

Density

1.165

Flash Point

83 °C

Refractive Index

1.377

SMILES

View in Editor

C1=CC=C(C=C1)C2=C(C=C(C=C2)F)F

InChI

InChI=1S/C12H8F2/c13-10-6-7-11(12(14)8-10)9-4-2-1-3-5-9/h1-8H

InChIKey

JVHAJKHGPDDEEU-UHFFFAOYSA-N

LogP

3.631800000000001

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

175

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

H315

H318

H335

H400

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

H400 Very toxic to aquatic life
Hazardous to the aquatic environment, acute hazard

Hazard Class

Class 9 Class 9

Synonyms & References

English

SCHEMBL412228
D90192
AC-10689
InChI=1/C12H8F2/c13-10-6-7-11(12(14)8-10)9-4-2-1-3-5-9/h1-8H
AS-13070
JVHAJKHGPDDEEU-UHFFFAOYSA-
37847-52-2
2,4-Difluoro-1,1-biphenyl
CS-W015898
2',4'-difluorobiphenyl
2,4-Difluoro-1,1'-biphenyl
2,4-Difluorobiphenyl
1,1'-Biphenyl, 2,4-difluoro-
EINECS 253-690-2
AKOS006230003
2,4-difluoro-1-phenylbenzene
JVHAJKHGPDDEEU-UHFFFAOYSA-N
2,4-Difluorophenylbenzene
2,4-Difluoro-1,1'-biphenyl, 97%
FT-0610097
RR42FH7YWL
DTXSID70191277
W-106508
2,4-Difluoro-biphenyl
MFCD00042515
CHEMBL121977
D3450
NS00057669
2,4-Difluorodiphenyl
2,4-difluorbiphenyl
PubChem8914

MDL Number

MFCD00042515

Customs Code

2903999090

FAQ

What are the physical and chemical properties of 2,4-Difluorobiphenyl (CAS: 37847-52-2)?

2,4-Difluorobiphenyl (CAS: 37847-52-2) is a solid with a crystalline form. It has a molecular weight of approximately 186.07 g/mol and a melting point of 48-49°C. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. It is moderately reactive towards nucleophiles and electrophiles. It has low toxicity but can cause irritation to the eyes and skin if exposed. It is used in the synthesis of pharmaceuticals and sensors.

How is 2,4-Difluorobiphenyl (CAS: 37847-52-2) typically synthesized?

2,4-Difluorobiphenyl (CAS: 37847-52-2) is typically synthesized via the coupling of 2-bromo-4-chlorobiphenyl with potassium fluoride in the presence of a base such as potassium carbonate. The reaction is performed under inert atmosphere to prevent side reactions. The yield is usually around 80%, and the product is purified by recrystallization to obtain the crystalline form.

What industries use 2,4-Difluorobiphenyl (CAS: 37847-52-2)?

2,4-Difluorobiphenyl (CAS: 37847-52-2) is used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. It is also used in the sensor industry, where its fluorinated groups enhance sensor sensitivity. Additionally, it is employed in the semiconductor industry for the production of organic light-emitting diodes (OLEDs) due to its electronic properties.

What precautions should be taken when handling 2,4-Difluorobiphenyl (CAS: 37847-52-2)?

When handling 2,4-Difluorobiphenyl (CAS: 37847-52-2), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. The work should be conducted in a well-ventilated area or a fume hood to minimize inhalation of fumes. Spills should be cleaned up immediately using appropriate absorbents and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.