2,4-Difluorobiphenyl(CAS: 37847-52-2)

2,4-Difluorobiphenyl (CAS: 37847-52-2) is a solid with a crystalline form. It has a molecular weight of approximately 186.07 g/mol and a melting point of 48-49°C. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. It is moderately reactive towards nucleophiles and electrophiles. It has low toxicity but can cause irritation to the eyes and skin if exposed. It is used in the synthesis of pharmaceuticals and sensors.

2,4-Difluorobiphenyl (CAS: 37847-52-2) is typically synthesized via the coupling of 2-bromo-4-chlorobiphenyl with potassium fluoride in the presence of a base such as potassium carbonate. The reaction is performed under inert atmosphere to prevent side reactions. The yield is usually around 80%, and the product is purified by recrystallization to obtain the crystalline form.

2,4-Difluorobiphenyl (CAS: 37847-52-2) is used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. It is also used in the sensor industry, where its fluorinated groups enhance sensor sensitivity. Additionally, it is employed in the semiconductor industry for the production of organic light-emitting diodes (OLEDs) due to its electronic properties.

When handling 2,4-Difluorobiphenyl (CAS: 37847-52-2), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. The work should be conducted in a well-ventilated area or a fume hood to minimize inhalation of fumes. Spills should be cleaned up immediately using appropriate absorbents and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.