2',4-Dihydroxy-4',6'-dimethoxychalcone

Basic Information

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CAS Number

37308-75-1

Molecular Formula

C17H16O5

Molecular Weight

300.31 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

179-182 ºC

SMILES

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COC1=CC(=C(C(=C1)OC)C(=O)C=CC2=CC=C(C=C2)O)O

InChI

InChI=1S/C17H16O5/c1-21-13-9-15(20)17(16(10-13)22-2)14(19)8-5-11-3-6-12(18)7-4-11/h3-10,18,20H,1-2H3/b8-5+

InChIKey

UXUFMIJZNYXWDX-VMPITWQZSA-N

LogP

3.0111000000000026

Topological Polar Surface Area

75.99000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

387

Safety Information

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Storage Conditions

2-8℃

Synonyms & References

English

(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
SureCN144230
Flavokavain C
flavokawin
AC1O3VJI
Flavokawain C
4',6'-dimethoxy-2',4-dihydroxychalcone
4',6'-di-O-methylchalconaringenin
1-(2-hydroxy-4,6-dimethoxy)phenyl-3-(4-hydroxy)phenyl-2-propen-1-one
2'-hydroxy-4,6'-dimethoxychalcone
2',4-dihydroxy-4',6'-dimethoxychalcone
Flavokawin C
AQ-358
2',4-Dihydroxy-4',6'-dimethoxy-trans-chalcone
1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Flavokavin C
1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
UXUFMIJZNYXWDX-VMPITWQZSA-N
LMPK12120320
4,2'-Dihydroxy-4',6'-dimethoxychalcone
ST50308956
Q5458168
2-Propen-1-one, 1-(2-hydroxy-4,6-dimeth
Flavokavin C,4-Hydroxyflavokawain B
FLAVOKAWAINC
56798-34-6
5LE8KTR6G2
SCHEMBL144230
DTXSID60958437
2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-
4-Hydroxyflavokawain B

MDL Number

MFCD00016489

FAQ

What are the physical and chemical properties of 2',4-Dihydroxy-4',6'-dimethoxychalcone (CAS: 37308-75-1)?

2',4-Dihydroxy-4',6'-dimethoxychalcone is a yellow crystalline solid with a molecular weight of approximately 280.27 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is known for its reactivity towards nucleophiles and its ability to undergo intramolecular cyclization under certain conditions.

How is 2',4-Dihydroxy-4',6'-dimethoxychalcone (CAS: 37308-75-1) typically synthesized?

2',4-Dihydroxy-4',6'-dimethoxychalcone is usually synthesized via a condensation reaction between 2-hydroxy-4',6'-dimethoxyacetophenone and a suitable aromatic aldehyde in the presence of an acid catalyst such as acetic acid. The reaction typically proceeds with good yield and selectivity.

What industries use 2',4-Dihydroxy-4',6'-dimethoxychalcone (CAS: 37308-75-1)?

2',4-Dihydroxy-4',6'-dimethoxychalcone is used in the pharmaceutical industry for the development of new drug candidates due to its potential anti-inflammatory and antioxidant properties. It is also utilized in the sensor industry for its ability to respond to certain chemical stimuli.

What precautions should be taken when handling 2',4-Dihydroxy-4',6'-dimethoxychalcone (CAS: 37308-75-1)?

When handling 2',4-Dihydroxy-4',6'-dimethoxychalcone, it is important to use personal protective equipment such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents and disposing of them according to local safety regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.