2',4-Dihydroxy-4',6'-dimethoxychalcone(CAS: 37308-75-1)

2',4-Dihydroxy-4',6'-dimethoxychalcone is a yellow crystalline solid with a molecular weight of approximately 280.27 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is known for its reactivity towards nucleophiles and its ability to undergo intramolecular cyclization under certain conditions.

2',4-Dihydroxy-4',6'-dimethoxychalcone is usually synthesized via a condensation reaction between 2-hydroxy-4',6'-dimethoxyacetophenone and a suitable aromatic aldehyde in the presence of an acid catalyst such as acetic acid. The reaction typically proceeds with good yield and selectivity.

2',4-Dihydroxy-4',6'-dimethoxychalcone is used in the pharmaceutical industry for the development of new drug candidates due to its potential anti-inflammatory and antioxidant properties. It is also utilized in the sensor industry for its ability to respond to certain chemical stimuli.

When handling 2',4-Dihydroxy-4',6'-dimethoxychalcone, it is important to use personal protective equipment such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents and disposing of them according to local safety regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.