7-Chloro-1H-pyrrolo[3,2-b]pyridine

Basic Information

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CAS Number

357263-48-0

Molecular Formula

C7H5ClN2

Molecular Weight

152.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

175-185°C

SMILES

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C1=CNC2=C(C=CN=C21)Cl

InChI

InChI=1S/C7H5ClN2/c8-5-1-3-9-6-2-4-10-7(5)6/h1-4,10H

InChIKey

ZBEYLQBHTDNDDR-UHFFFAOYSA-N

LogP

2.2162999999999995

Topological Polar Surface Area

28.68 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

129

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DTXSID60625935
SCHEMBL1473269
MFCD08234945
1H-Pyrrolo[3,2-b]pyridine, 7-chloro-
PB14564
7-Chloro-1H-pyrrolo[3 pound not2-b]pyridine
A21610
AKOS006284018
CS-W019635
J-519204
357263-48-0
7-Chloro-4-azaindole
ZBEYLQBHTDNDDR-UHFFFAOYSA-N
FT-0656686
BCP27399
7-CHLORO-1H-PYRROLO[3,2-B]PYRIDINE
AC-22982
EN300-94604
AS-18317
SY097793
AMY7457
7-chloro-1H-Pyrrolo[3,2-b]pyridine
1H-Pyrrolo[3,2-b]pyridine,7-chloro-
HIN1541
PubChem24160
KSC496Q1B
WT1459
FCH858809
AS07101
ST1271498
AB0024448

MDL Number

MFCD08234945

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 7-Chloro-1H-pyrrolo[3,2-b]pyridine (CAS: 357263-48-0)?

7-Chloro-1H-pyrrolo[3,2-b]pyridine is a white to off-white solid with a molecular weight of approximately 210.01 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and acetonitrile. It is stable under normal conditions but can react with bases to form chlorides. Its solubility and reactivity make it suitable for various chemical applications.

How is 7-Chloro-1H-pyrrolo[3,2-b]pyridine (CAS: 357263-48-0) typically synthesized?

7-Chloro-1H-pyrrolo[3,2-b]pyridine is synthesized via a multi-step procedure involving the chlorination of 1H-pyrrolo[3,2-b]pyridine. The reaction is typically carried out using thionyl chloride in an inert solvent like toluene. The yield is around 85%, and the method involves careful temperature control to achieve high selectivity and purity.

What industries use 7-Chloro-1H-pyrrolo[3,2-b]pyridine (CAS: 357263-48-0)?

7-Chloro-1H-pyrrolo[3,2-b]pyridine is primarily used in the pharmaceutical industry for the development of antiviral and anticancer drugs. It is also utilized in the manufacturing of sensors and as an intermediate in the synthesis of other compounds. Its applications span across the pharmaceutical, chemical, and sensor industries.

What precautions should be taken when handling 7-Chloro-1H-pyrrolo[3,2-b]pyridine (CAS: 357263-48-0)?

When handling 7-Chloro-1H-pyrrolo[3,2-b]pyridine, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be immediately cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.