7-Chloro-1H-pyrrolo[3,2-b]pyridine(CAS: 357263-48-0)

7-Chloro-1H-pyrrolo[3,2-b]pyridine is a white to off-white solid with a molecular weight of approximately 210.01 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and acetonitrile. It is stable under normal conditions but can react with bases to form chlorides. Its solubility and reactivity make it suitable for various chemical applications.

7-Chloro-1H-pyrrolo[3,2-b]pyridine is synthesized via a multi-step procedure involving the chlorination of 1H-pyrrolo[3,2-b]pyridine. The reaction is typically carried out using thionyl chloride in an inert solvent like toluene. The yield is around 85%, and the method involves careful temperature control to achieve high selectivity and purity.

7-Chloro-1H-pyrrolo[3,2-b]pyridine is primarily used in the pharmaceutical industry for the development of antiviral and anticancer drugs. It is also utilized in the manufacturing of sensors and as an intermediate in the synthesis of other compounds. Its applications span across the pharmaceutical, chemical, and sensor industries.

When handling 7-Chloro-1H-pyrrolo[3,2-b]pyridine, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be immediately cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.