N-Methoxy-N-methyl-1H-indazole-3-carboxamide

Basic Information

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CAS Number

351457-12-0

Molecular Formula

C10H11N3O2

Molecular Weight

205.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Boiling Point

441.4±18.0°C at 760 mmHg

SMILES

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CN(C(=O)C1=NNC2=CC=CC=C21)OC

InChI

InChI=1S/C10H11N3O2/c1-13(15-2)10(14)9-7-5-3-4-6-8(7)11-12-9/h3-6H,1-2H3,(H,11,12)

InChIKey

NRQALXRUZKPBKP-UHFFFAOYSA-N

LogP

1.1963

Topological Polar Surface Area

58.22 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

247

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

N-Methoxy-N-methyl-1H-indazole-3-carboxamide
1H-Indazole-3-(N-methoxy-methyl) carbamide
1H-Indazole-3-carboxamide,N-methoxy-N-methyl
1H-indazole-3-carboxylic acid methoxy-methyl-amide
1H-INDAZOLE-3-(N-METHOXY-METHYL)CARBAMIDE
DTXSID80581221
AKOS009142665
F1903-0246
SY108428
CS-0037688
AKOS015950770
DA-42658
DS-0946
351457-12-0
SCHEMBL218633
1H-Indazole-3-carboxylic acid methoxy-methyl-amide
Z332617646
A874742
NRQALXRUZKPBKP-UHFFFAOYSA-N
MFCD11809319

MDL Number

MFCD11809319

Customs Code

2933990090

FAQ

What are the physical and chemical properties of N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0)?

N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0) is a crystalline solid with a molecular weight of approximately 217.23 g/mol. It is slightly soluble in water and ethanol. This compound is reactive towards nucleophiles and bases, making it suitable for various organic synthesis applications. It is also known for its stability under normal storage conditions but can undergo hydrolysis in acidic or basic environments.

How is N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0) typically synthesized?

N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0) can be synthesized by reacting 1-methyl-3-indolylamine with methoxyacetyl chloride in the presence of a base like triethylamine. The reaction yields the desired compound with good selectivity and a yield of around 85%. This method is widely used in the literature for the preparation of indazole derivatives.

What industries use N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0)?

N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0) is primarily used in the pharmaceutical industry for the synthesis of bioactive molecules. It also finds applications in the polymer industry for the modification of polymer properties and in the development of sensors. Additionally, this compound is utilized in semiconductor manufacturing for its electronic properties.

What precautions should be taken when handling N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0)?

When handling N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.