N-Methoxy-N-methyl-1H-indazole-3-carboxamide(CAS: 351457-12-0)

N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0) is a crystalline solid with a molecular weight of approximately 217.23 g/mol. It is slightly soluble in water and ethanol. This compound is reactive towards nucleophiles and bases, making it suitable for various organic synthesis applications. It is also known for its stability under normal storage conditions but can undergo hydrolysis in acidic or basic environments.

N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0) can be synthesized by reacting 1-methyl-3-indolylamine with methoxyacetyl chloride in the presence of a base like triethylamine. The reaction yields the desired compound with good selectivity and a yield of around 85%. This method is widely used in the literature for the preparation of indazole derivatives.

N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0) is primarily used in the pharmaceutical industry for the synthesis of bioactive molecules. It also finds applications in the polymer industry for the modification of polymer properties and in the development of sensors. Additionally, this compound is utilized in semiconductor manufacturing for its electronic properties.

When handling N-Methoxy-N-methyl-1H-indazole-3-carboxamide (CAS: 351457-12-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.