(6-Fluoro-3-pyridinyl)boronic acid

Basic Information

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CAS Number

351019-18-6

Molecular Formula

C5H5BFNO2

Molecular Weight

140.91 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

172°C(dec.)

Boiling Point

326.8℃ at 760 mmHg

Density

1.3400

Flash Point

142.2 °C

Refractive Index

1.507

SMILES

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B(C1=CN=C(C=C1)F)(O)O

InChI

InChI=1S/C5H5BFNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3,9-10H

InChIKey

OJBYZWHAPXIJID-UHFFFAOYSA-N

LogP

-1.0995000000000001

Topological Polar Surface Area

53.35 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

114

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

OJBYZWHAPXIJID-UHFFFAOYSA-N
2-fluoro-5-pyridine boronic acid
GS-6798
(6-fluoro-3-pyridinyl)boronic acid
AM20051109
6-Fluoro-3-pyridinylboronic acid
MFCD03411559
6-fluoro-pyridine-3-boronic acid
SY022130
6-fluoropyridin-3-yl boronic acid
J-509527
6-fluoropyridine-3-boronic acid
2-fluoro-5-pyridineboronic acid
351019-18-6
(6-fluoropyridin-3-yl)boranediol
BDBM26141
6-Fluoro-3-pyridylboronic Acid
6-FLUORO-3-PYRIDINEBORONIC ACID
(6-fluoropyridin-3-yl) boronic acid
HY-32952
2-fluoropyridin-5-ylboronic acid
BORONIC ACID, (6-FLUORO-3-PYRIDINYL)-
CS-D1045
(6-fluoropyridin-3-yl)boronic Acid
DTXSID00382636
(6-fluoro-3-pyridyl)boronic acid
6-fluoro-pyridin-3-ylboronic acid
SCHEMBL8593
2-Fluoropyridine-5-boronic acid
AC-6986
2-Fluoro-5-pyridylboronicacid

MDL Number

MFCD03411559

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (6-Fluoro-3-pyridinyl)boronic acid (CAS: 351019-18-6)?

(6-Fluoro-3-pyridinyl)boronic acid is a crystalline solid with a molecular weight of approximately 214.07 g/mol. It has a low solubility in water (0.1 g/L at 25°C) but is more soluble in organic solvents like methanol and ethanol. Chemically, it exhibits reactivity typical of boronic acids, such as electrophilic aromatic substitution reactions and hydrogen bonding. It is stable under normal conditions but should be handled with care due to its sensitivity to strong acids and bases.

How is (6-Fluoro-3-pyridinyl)boronic acid (CAS: 351019-18-6) typically synthesized?

(6-Fluoro-3-pyridinyl)boronic acid can be synthesized through the reaction of 6-fluoro-3-pyridine carboxylic acid with a boron reagent such as pinacol boronate in the presence of a base like sodium carbonate. This synthesis yields a high purity product with good yield, typically around 85-90%. The process is selective and can be carried out under mild conditions, making it suitable for laboratory-scale production.

What industries use (6-Fluoro-3-pyridinyl)boronic acid (CAS: 351019-18-6)?

(6-Fluoro-3-pyridinyl)boronic acid has applications in pharmaceuticals, where it can be used as a building block for drug synthesis. It also finds use in the polymer industry for modifying polymer properties and in electronic applications such as semiconductors due to its electronic characteristics. Additionally, it is utilized in various analytical and sensor technologies for its reactivity and stability.

What precautions should be taken when handling (6-Fluoro-3-pyridinyl)boronic acid (CAS: 351019-18-6)?

When handling (6-Fluoro-3-pyridinyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of any generated fumes. In case of spill, immediately clean up with water and appropriate spill kits. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions. Storage should be in a cool, dry place away from strong acids and bases.