(6-Fluoro-3-pyridinyl)boronic acid(CAS: 351019-18-6)

(6-Fluoro-3-pyridinyl)boronic acid is a crystalline solid with a molecular weight of approximately 214.07 g/mol. It has a low solubility in water (0.1 g/L at 25°C) but is more soluble in organic solvents like methanol and ethanol. Chemically, it exhibits reactivity typical of boronic acids, such as electrophilic aromatic substitution reactions and hydrogen bonding. It is stable under normal conditions but should be handled with care due to its sensitivity to strong acids and bases.

(6-Fluoro-3-pyridinyl)boronic acid can be synthesized through the reaction of 6-fluoro-3-pyridine carboxylic acid with a boron reagent such as pinacol boronate in the presence of a base like sodium carbonate. This synthesis yields a high purity product with good yield, typically around 85-90%. The process is selective and can be carried out under mild conditions, making it suitable for laboratory-scale production.

(6-Fluoro-3-pyridinyl)boronic acid has applications in pharmaceuticals, where it can be used as a building block for drug synthesis. It also finds use in the polymer industry for modifying polymer properties and in electronic applications such as semiconductors due to its electronic characteristics. Additionally, it is utilized in various analytical and sensor technologies for its reactivity and stability.

When handling (6-Fluoro-3-pyridinyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of any generated fumes. In case of spill, immediately clean up with water and appropriate spill kits. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions. Storage should be in a cool, dry place away from strong acids and bases.