5-Hydroxy-1-indanone

Basic Information

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CAS Number

3470-49-3

Molecular Formula

C9H8O2

Molecular Weight

148.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

175 °C (dec.)

Boiling Point

343.8°C at 760 mmHg

Density

1.3050

Flash Point

146.4℃

Refractive Index

1.631

SMILES

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C1CC(=O)C2=C1C=C(C=C2)O

InChI

InChI=1S/C9H8O2/c10-7-2-3-8-6(5-7)1-4-9(8)11/h2-3,5,10H,1,4H2

InChIKey

ZRKQOVXGDIZYDS-UHFFFAOYSA-N

LogP

1.5211

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

176

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

5-hydroxy-2,3-dihydroinden-1-one
5-hydroxy-dihydro-inden-1-one
5-hydroxyindan-1-one;5-Hydroxy-1-indanone
SY002061
NSC-31249
AKOS005207246
1H-Inden-1-one, 2,3-dihydro-5-hydroxy-
H1051
AM20040235
Z1255457932
MFCD00857527
5-Hydroxy-1 indanone
3470-49-3
5-hydroxyindan-1-one
J-019721
2,3-Dihydro-5-hydroxy-1H-inden-1-one
5-Hydroxy-1-indanone
5-hydroxy-2,3-dihydro-1H-indene-1-one
5-Hydroxy-indan-1 -one
EN300-156504
SCHEMBL389710
FT-0634872
5-hydroxy-indan-1-one
5-Hydroxy-1-indanone, 95%
NSC31249
ZRKQOVXGDIZYDS-UHFFFAOYSA-N
PS-3391
AE-848/00220058
InChI=1/C9H8O2/c10-7-2-3-8-6(5-7)1-4-9(8)11/h2-3,5,10H,1,4H
DTXSID70283404
5-hydroxy-2,3-dihydro-inden-1-one

MDL Number

MFCD00857527

Customs Code

2914400090

FAQ

What are the physical and chemical properties of 5-Hydroxy-1-indanone (CAS: 3470-49-3)?

5-Hydroxy-1-indanone (CAS: 3470-49-3) is a colorless, crystalline solid with a molecular weight of approximately 144.19 g/mol. It has a melting point of 128-129°C and a boiling point of 246-247°C. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It is reactive towards bases and strongly oxidizing agents.

How is 5-Hydroxy-1-indanone (CAS: 3470-49-3) typically synthesized?

5-Hydroxy-1-indanone (CAS: 3470-49-3) is usually synthesized via the indanone ring closure and subsequent hydroxylation of an appropriate ketone. A common method involves the Wittig reaction followed by hydroxylation using hydrogen peroxide in the presence of a suitable catalyst like tetrabutylammonium hydroxide. The yield can be up to 90%, depending on the purity of the starting materials and reaction conditions.

What industries use 5-Hydroxy-1-indanone (CAS: 3470-49-3)?

5-Hydroxy-1-indanone (CAS: 3470-49-3) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the production of polymers and as a precursor in the manufacturing of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 5-Hydroxy-1-indanone (CAS: 3470-49-3)?

When handling 5-Hydroxy-1-indanone (CAS: 3470-49-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be stored in a well-ventilated area away from heat sources and oxidizing agents. In case of a spill, it should be handled in a fume hood, and the appropriate safety data sheet (SDS) should be consulted for detailed instructions. Follow all standard chemical hygiene practices to ensure laboratory safety.