Compound Q&A

How is 5-Hydroxy-1-indanone (CAS: 3470-49-3) typically synthesized?

Answer

5-Hydroxy-1-indanone
5-Hydroxy-1-indanone (CAS: 3470-49-3) is usually synthesized via the indanone ring closure and subsequent hydroxylation of an appropriate ketone. A common method involves the Wittig reaction followed by hydroxylation using hydrogen peroxide in the presence of a suitable catalyst like tetrabutylammonium hydroxide. The yield can be up to 90%, depending on the purity of the starting materials and reaction conditions.

About

CAS No 3470-49-3
English Name 5-Hydroxy-1-indanone
Molecular Formula C9H8O2
Molecular Weight 148.16 g/mol
SMILES C1CC(=O)C2=C1C=C(C=C2)O
InChIKey ZRKQOVXGDIZYDS-UHFFFAOYSA-N
Last Updated: 2025-10-13 12:55

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