5-Hydroxy-1-indanone(CAS: 3470-49-3)

5-Hydroxy-1-indanone (CAS: 3470-49-3) is a colorless, crystalline solid with a molecular weight of approximately 144.19 g/mol. It has a melting point of 128-129°C and a boiling point of 246-247°C. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It is reactive towards bases and strongly oxidizing agents.

5-Hydroxy-1-indanone (CAS: 3470-49-3) is usually synthesized via the indanone ring closure and subsequent hydroxylation of an appropriate ketone. A common method involves the Wittig reaction followed by hydroxylation using hydrogen peroxide in the presence of a suitable catalyst like tetrabutylammonium hydroxide. The yield can be up to 90%, depending on the purity of the starting materials and reaction conditions.

5-Hydroxy-1-indanone (CAS: 3470-49-3) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the production of polymers and as a precursor in the manufacturing of sensors and semiconductors due to its unique chemical properties.

When handling 5-Hydroxy-1-indanone (CAS: 3470-49-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be stored in a well-ventilated area away from heat sources and oxidizing agents. In case of a spill, it should be handled in a fume hood, and the appropriate safety data sheet (SDS) should be consulted for detailed instructions. Follow all standard chemical hygiene practices to ensure laboratory safety.