2-(Trifluoromethyl)quinoline

Basic Information

View in Editor

CAS Number

347-42-2

Molecular Formula

C10H6F3N

Molecular Weight

197.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

58-62 °C

Boiling Point

233 ºC

Flash Point

90.7±25.9 ºC,

SMILES

View in Editor

C1=CC=C2C(=C1)C=CC(=N2)C(F)(F)F

InChI

InChI=1S/C10H6F3N/c11-10(12,13)9-6-5-7-3-1-2-4-8(7)14-9/h1-6H

InChIKey

YZSRICFIQLVSMQ-UHFFFAOYSA-N

LogP

3.2536000000000005

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

202

Safety Information

View Safety Information

GHS Hazard Pictograms

H301

H315

H319

H335

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SB36752
FT-0651356
DTXSID10380663
2-(Trifluoromethyl)quinoline, 97%
2-(trifluoromethyl)quinoline
SCHEMBL873852
2-trifluoromethylquinoline
347-42-2
AM20051100
DS-17173
TD8148
(trifluoromethyl)quinoline
2-Trifluoromethyl-quinoline
A25656
AKOS000320169
EN300-101411
Q-103521
MFCD01862002
2-(Trifluoromethyl)quinoline
2-TRIFLUOROMETHYLQUINOLINE
Quinoline,2-(trifluoromethyl)-
2-(trifluoromethyl)-quinoline
2-(trifluoromethyl)quinolone
Quinoline,2-(trifluoromethyl)
PubChem23495
YZSRICFIQLVSMQ-UHFFFAOYSA-N
FCH918069
STL554821
SBB092122
PC0944
CT0072

MDL Number

MFCD01862002

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 2-(Trifluoromethyl)quinoline (CAS: 347-42-2)?

2-(Trifluoromethyl)quinoline (CAS: 347-42-2) is a crystalline compound with a molecular weight of approximately 257.07 g/mol. It has a low water solubility and is sparingly soluble in common organic solvents. The compound is known for its high reactivity towards nucleophiles and its tendency to form stable complexes with transition metals. It is stable under typical laboratory conditions but should be handled with care to avoid prolonged exposure to air and moisture.

How is 2-(Trifluoromethyl)quinoline (CAS: 347-42-2) typically synthesized?

2-(Trifluoromethyl)quinoline (CAS: 347-42-2) is typically synthesized via the condensation of 1,4-dibromonaphthalene with trifluoroacetic anhydride. The reaction is catalyzed by a strong base such as potassium tert-butoxide and proceeds with good yield. The product is purified by recrystallization from ethanol, yielding a crystalline form suitable for further applications.

What industries use 2-(Trifluoromethyl)quinoline (CAS: 347-42-2)?

2-(Trifluoromethyl)quinoline (CAS: 347-42-2) is used in various industries, including pharmaceuticals, where it serves as a building block for drug synthesis. It is also employed in the field of organic semiconductor materials for the development of novel electronic devices. Additionally, its unique properties make it valuable in the synthesis of fluorescent dyes and sensors.

What precautions should be taken when handling 2-(Trifluoromethyl)quinoline (CAS: 347-42-2)?

When handling 2-(Trifluoromethyl)quinoline (CAS: 347-42-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be handled carefully, and the area should be cleaned with water and detergent. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.