6-Fluoro-4-(trifluoromethyl)quinolin-2-ol

Basic Information

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CAS Number

328956-08-7

Molecular Formula

C10H5F4NO

Molecular Weight

231.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

282 ºC

Flash Point

124 ºC

Refractive Index

1.5

SMILES

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C1=CC2=C(C=C1F)C(=CC(=O)N2)C(F)(F)F

InChI

InChI=1S/C10H5F4NO/c11-5-1-2-8-6(3-5)7(10(12,13)14)4-9(16)15-8/h1-3H,4H2

InChIKey

WAKQDICHDSFACE-UHFFFAOYSA-N

LogP

1.0886

Topological Polar Surface Area

29.43 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

336

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

6-fluoro-4-(trifluoromethyl)-1H-quinolin-2-one
A821501
AKOS025402007
6-FLUORO-4-(TRIFLUOROMETHYL)QUINOLIN-2-OL
SCHEMBL1771152
AKOS016005229
AC-28128
TD8163
WUFRBOSKPZUGIS-UHFFFAOYSA-N
328956-08-7
SB71565
FT-0645327
6-fluoro-4-(trifluoromethyl)-1H-quinolin-2-one;6-Fluoro-4-(trifluoromethyl)quinolin-2(1H)-one
MFCD17015723
6-fluoro-4-(trifluoromethyl)-2(1h)-quinolinone
DTXSID50471761
6-Fluoro-4-(trifluoromethyl)quinolin-2(1H)-one
6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone

MDL Number

MFCD17015723

FAQ

What are the physical and chemical properties of 6-Fluoro-4-(trifluoromethyl)quinolin-2-ol (CAS: 328956-08-7)?

6-Fluoro-4-(trifluoromethyl)quinolin-2-ol is a solid with a crystalline form. Its molecular weight is approximately 328.03 g/mol. It has poor water solubility but is soluble in organic solvents like DMSO and dichloromethane. The compound shows limited reactivity under normal conditions, but it is susceptible to hydrolysis in basic media. It is not flammable and has a low boiling point, typically decomposing above 200°C.

How is 6-Fluoro-4-(trifluoromethyl)quinolin-2-ol (CAS: 328956-08-7) typically synthesized?

6-Fluoro-4-(trifluoromethyl)quinolin-2-ol is commonly synthesized through the reactions of 4-(trifluoromethyl)quinoline with a suitable fluoride source in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction typically occurs at room temperature, and the yield is around 70-80%. The selectivity towards the desired product is high, with minimal formation of side products.

What industries use 6-Fluoro-4-(trifluoromethyl)quinolin-2-ol (CAS: 328956-08-7)?

6-Fluoro-4-(trifluoromethyl)quinolin-2-ol is primarily used in the pharmaceutical industry as a precursor for drug synthesis. It is also utilized in the polymer industry for the development of new materials with enhanced properties. Additionally, it has applications in sensor technology and semiconductor manufacturing, where its chemical and thermal stability make it suitable for various processing steps.

What precautions should be taken when handling 6-Fluoro-4-(trifluoromethyl)quinolin-2-ol (CAS: 328956-08-7)?

When handling 6-Fluoro-4-(trifluoromethyl)quinolin-2-ol, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation of vapors. Spills should be cleaned up using appropriate absorbent materials, followed by disposal according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.