Compound Q&A
How is 6-Fluoro-4-(trifluoromethyl)quinolin-2-ol (CAS: 328956-08-7) typically synthesized?
Answer
6-Fluoro-4-(trifluoromethyl)quinolin-2-ol is commonly synthesized through the reactions of 4-(trifluoromethyl)quinoline with a suitable fluoride source in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction typically occurs at room temperature, and the yield is around 70-80%. The selectivity towards the desired product is high, with minimal formation of side products.
About
CAS No
328956-08-7
English Name
6-Fluoro-4-(trifluoromethyl)quinolin-2-ol
Molecular Formula
C10H5F4NO
Molecular Weight
231.15 g/mol
SMILES
C1=CC2=C(C=C1F)C(=CC(=O)N2)C(F)(F)F
InChIKey
WAKQDICHDSFACE-UHFFFAOYSA-N
Last Updated: 2025-10-28 15:15
