(3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Basic Information

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CAS Number

32233-40-2

Molecular Formula

C8H12O4

Molecular Weight

172.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

114.0 to 118.0 deg-C

Boiling Point

406.6°C at 760 mmHg

Flash Point

172.9±16.7 °C

Refractive Index

1.4455 (estimate)

SMILES

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O=C1C[C@@]([C@@H](CO)[C@H](O)C2)([H])[C@@]2([H])O1

InChI

InChI=1S/C8H12O4/c9-3-5-4-1-8(11)12-7(4)2-6(5)10/h4-7,9-10H,1-3H2/t4-,5-,6-,7+/m1/s1

InChIKey

VYTZWRCSPHQSFX-GBNDHIKLSA-N

LogP

-0.7088000000000003

Topological Polar Surface Area

66.76 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

203

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one
(-)-6beta-Hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one
(3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one
(-)-Corey Lactone
(-)-CoreyLactoneDiol
(3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-hydroxymethyl-2H-cyclopenta[b]furan-2-one
(3aR,4S,5R,6aS)-(?)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
(3AR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-hexahydro-2H-cyclopenta[b]furan-2-one
2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-(hydroxymethyl)-, (3aR,4S,5R,6aS)-
(−)-Corey Lactone Diol
(-)-Corey Diol (Corey Lactone)
(-)-Corey lactone diol

MDL Number

MFCD00075234

Customs Code

2932209090

FAQ

What is (3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one (CAS: 32233-40-2)?

This compound is a cyclic ether with a complex stereochemical structure, featuring hydroxyl groups at positions 5 and 4. Its chemical formula is C7H12O3, and it exhibits polar characteristics due to the hydroxyl functionalities. It is commonly used as a synthetic intermediate in organic chemistry and pharmaceutical research, known for its stability under controlled conditions.

What are the main uses of (3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one (CAS: 32233-40-2)?

This compound serves as a key intermediate in pharmaceutical synthesis, particularly for developing drugs with specific stereochemical requirements. It is also utilized in industrial organic chemistry for creating complex molecules and in research for studying reaction mechanisms. Its applications may extend to food additives and specialty chemical manufacturing, depending on further derivatization.

Is (3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one (CAS: 32233-40-2) safe?

While generally considered safe in controlled environments, this compound requires proper handling to avoid potential skin or respiratory irritation. Safety standards emphasize the use of protective equipment such as gloves and goggles when working with it. It is important to follow established OSHA and EPA guidelines to ensure safe usage and minimize exposure risks.

How should (3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one (CAS: 32233-40-2) be stored?

This compound should be stored in a cool, dry place, away from light, in a sealed container to prevent moisture absorption. It is stable under normal storage conditions but requires protection from air and heat to maintain integrity. Storage precautions include maintaining low humidity levels and ensuring proper ventilation to avoid any potential chemical degradation.