Methyl 2-amino-5-fluorobenzoate

Basic Information

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CAS Number

319-24-4

Molecular Formula

C8H8FNO2

Molecular Weight

169.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

34-37°C

Boiling Point

102°C/0.5mmHg

Flash Point

132℃

Refractive Index

1.338

SMILES

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COC(=O)C1=C(C=CC(=C1)F)N

InChI

InChI=1S/C8H8FNO2/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4H,10H2,1H3

InChIKey

PUDDYSBKCDKATP-UHFFFAOYSA-N

LogP

1.1945

Topological Polar Surface Area

52.32 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

174

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

4-Fluoro-2-(methoxycarbonyl)aniline
M2899
MFCD03791308
EN300-42149
Methyl 2-amino-5-fluorobenzoate
PUDDYSBKCDKATP-UHFFFAOYSA-N
BENZOIC ACID, 2-AMINO-5-FLUORO-, METHYL ESTER
AKOS005255207
SCHEMBL165608
CS-W007783
methyl2-amino-5-fluorobenzoate
A5752
2-Amino-5-fluoro-benzoic acid methyl ester
AC-3881
2-Amino-5-fluorobenzoic acid methyl ester
2-amino-5-fluoro benzoic acid methyl ester
PS-8717
methyl-2-amino-5-fluorobenzoate
DTXSID80382639
METHYL 5-FLUOROANTHRANILATE
BP-21337
319-24-4
EC 608-681-1
AMY18124
methyl 2-amino-5-fluoro-benzoate
NS00008132
FT-0612082
Z54593024
5-Fluoroanthranilic Acid Methyl Ester
SY009285
2-AMINO-5-FLUORO BENZOIC ACID METHYL ESTER

MDL Number

MFCD03791308

Customs Code

2922499990

FAQ

What are the physical and chemical properties of Methyl 2-amino-5-fluorobenzoate (CAS: 319-24-4)?

Methyl 2-amino-5-fluorobenzoate is a white crystalline solid with a molecular weight of 187.15 g/mol. It has a melting point of 106-108°C and is slightly soluble in water. The compound is moderately reactive, particularly towards nucleophilic substitution reactions. It is stable under normal storage conditions but should be protected from moisture and light.

How is Methyl 2-amino-5-fluorobenzoate (CAS: 319-24-4) typically synthesized?

Methyl 2-amino-5-fluorobenzoate can be synthesized via the reaction of 5-fluorobenzoic acid with methylamine. The reaction typically proceeds in the presence of an acid catalyst such as hydrochloric acid or trifluoroacetic acid. The yield is around 75-80%, and the reaction is selective towards the amide formation. The product can be purified by recrystallization from ethanol or methanol.

What industries use Methyl 2-amino-5-fluorobenzoate (CAS: 319-24-4)?

Methyl 2-amino-5-fluorobenzoate is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry for the development of specific polymers and in the sensor and semiconductor industries for the production of specialized materials. Its unique chemical properties make it valuable in these applications.

What precautions should be taken when handling Methyl 2-amino-5-fluorobenzoate (CAS: 319-24-4)?

When handling Methyl 2-amino-5-fluorobenzoate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up immediately using absorbent materials and proper disposal methods. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.