Compound Q&A
How is Methyl 2-amino-5-fluorobenzoate (CAS: 319-24-4) typically synthesized?
Answer
Methyl 2-amino-5-fluorobenzoate can be synthesized via the reaction of 5-fluorobenzoic acid with methylamine. The reaction typically proceeds in the presence of an acid catalyst such as hydrochloric acid or trifluoroacetic acid. The yield is around 75-80%, and the reaction is selective towards the amide formation. The product can be purified by recrystallization from ethanol or methanol.
About
CAS No
319-24-4
English Name
Methyl 2-amino-5-fluorobenzoate
Molecular Formula
C8H8FNO2
Molecular Weight
169.16 g/mol
SMILES
COC(=O)C1=C(C=CC(=C1)F)N
InChIKey
PUDDYSBKCDKATP-UHFFFAOYSA-N
Last Updated: 2025-10-13 12:55
