Methyl 2-amino-5-fluorobenzoate(CAS: 319-24-4)

Methyl 2-amino-5-fluorobenzoate is a white crystalline solid with a molecular weight of 187.15 g/mol. It has a melting point of 106-108°C and is slightly soluble in water. The compound is moderately reactive, particularly towards nucleophilic substitution reactions. It is stable under normal storage conditions but should be protected from moisture and light.

Methyl 2-amino-5-fluorobenzoate can be synthesized via the reaction of 5-fluorobenzoic acid with methylamine. The reaction typically proceeds in the presence of an acid catalyst such as hydrochloric acid or trifluoroacetic acid. The yield is around 75-80%, and the reaction is selective towards the amide formation. The product can be purified by recrystallization from ethanol or methanol.

Methyl 2-amino-5-fluorobenzoate is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry for the development of specific polymers and in the sensor and semiconductor industries for the production of specialized materials. Its unique chemical properties make it valuable in these applications.

When handling Methyl 2-amino-5-fluorobenzoate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up immediately using absorbent materials and proper disposal methods. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.