Evans blue | CAS No. 314-13-6

Evans blue

Basic Information

View in Editor

CAS Number

314-13-6

Molecular Formula

C34H24N6Na4O14S4

Molecular Weight

960.8 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

°Cat760mmHg

Water Solubility

280 g/L (20 ºC)

SMILES

View in Editor

CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(C4=C(C=C3)C(=CC(=C4N)S(=O)(=O)[O-])S(=O)(=O)[O-])O)C)N=NC5=C(C6=C(C=C5)C(=CC(=C6N)S(=O)(=O)[O-])S(=O)(=O)[O-])O.[Na+].[Na+].[Na+].[Na+]

InChI

InChI=1S/C34H28N6O14S4.4Na/c1-15-11-17(3-7-21(15)37-39-23-9-5-19-25(55(43,44)45)13-27(57(49,50)51)31(35)29(19)33(23)41)18-4-8-22(16(2)12-18)38-40-24-10-6-20-26(56(46,47)48)14-28(58(52,53)54)32(36)30(20)34(24)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4

InChIKey

ATNOAWAQFYGAOY-UHFFFAOYSA-J

LogP

10.78520

Complexity

1790

Safety Information

View Safety Information

GHS Hazard Pictograms

H350

Hazard Statement

H350 May cause cancer
Carcinogenicity

Hazard Class

Class 6.1 Class 6.1

Stability

Stable. Incompatible with strong reducing agents, strong oxidizing agents.

Synonyms & References

English

Evablin
Blekit evansa
Dye Evans Blue
1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(4-amino-5-hydroxy-, sodium salt (1:4)
EVAN'S BLUE [MI]
4,4'-Bis(1-amino-8-hydroxy-2,4-disulpho-7-naphthylazo)-3,3'-bitolyl, tetrasodium salt
C34H24N6Na4O14S4
C.I. Direct Blue 53, tetrasodium salt
45PG892GO1
tetrasodium 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)
sodium 6,6'-(1E,1'E)-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(diazene-2,1-diyl)bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)
CCG-213687
tetrasodium 6,6'-[(3,3'-dimethyl-4,4'-biphenyldiyl)bis(2,1-diazenediyl)]bis(4-amino-5-hydroxy-1,3-naphthalenedisulfonate)
Direct Blue 53
C.I. direct blue 53 tetrasodium salt
Azovan Blue
Blekit evansa [Polish]
H10520
EINECS 206-242-5
Geigy-blau 536
Direct Blue 53; C.I. 23860
Diazobleu
Tox21_110929
314-13-6
4,4'-Bis(7-(1-amino-8-hydroxy-2,4-disulfo)naphthylazo)-3,3'-bitolyl, tetrasodium salt
Diazol Pure Blue BF
4,4'-Bis(1-amino-8-hydroxy-2,4-disulfo-7-naphthylazo)-3,3'-bitolyl, tetrasodium salt
Evan's Blue
EVANS BLUE [IARC]
Tetrasodium 6,6'-(3,3'-dimethyl-(1,1'-biphenyl)-4,4'diyl)bis(azo)bis(4-amino-5-hydroxy-1,3-naphthalenedisulphonate)
Direct blue 53 tetrasodium salt

MDL Number

MFCD00004021

FAQ

What are the physical and chemical properties of Evans blue (CAS: 314-13-6)?

Evans blue (CAS: 314-13-6) is a water-soluble dye with a molecular weight of approximately 406.14 g/mol. It has a deep blue color and is highly soluble in water. Chemically, it is less reactive and is commonly used in pharmaceuticals and biotechnology for staining cells and tissues. It does not readily react with other compounds under normal conditions.

How is Evans blue (CAS: 314-13-6) typically synthesized?

Evans blue (CAS: 314-13-6) is synthesized from 4,4'-diamino-3,3'-diethylbenzidine and hydroxyquinoline. The reaction involves a condensation step followed by sulfonation, which yields the characteristic blue dye. The process requires careful control of pH and temperature to ensure high yield and selectivity.

What industries use Evans blue (CAS: 314-13-6)?

Evans blue (CAS: 314-13-6) is widely used in various industries. It is primarily used in pharmaceuticals for cell and tissue staining, in biotechnology for molecular biology applications, and in medical diagnostics. It also has applications in sensor technology and as a reference dye in certain analytical techniques.

What precautions should be taken when handling Evans blue (CAS: 314-13-6)?

When handling Evans blue (CAS: 314-13-6), it is essential to wear appropriate personal protective equipment (PPE), including gloves and lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of dust. Spills should be cleaned up immediately using appropriate chemical spill kits. Always consult the Safety Data Sheet (SDS) for detailed safety information and handling procedures.