2-Bromo-4-chlorothieno[3,2-c]pyridine

Basic Information

View in Editor

CAS Number

28948-61-0

Molecular Formula

C7H3BrClNS

Molecular Weight

248.53 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Solid

SMILES

View in Editor

C1=CN=C(C2=C1SC(=C2)Br)Cl

InChI

InChI=1S/C7H3BrClNS/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1-3H

InChIKey

QPGCPWZFCLBFCG-UHFFFAOYSA-N

LogP

3.712200000000001

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

157

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

J-508276
AM20061854
AKOS015851172
MFCD08273916
28948-61-0
CS-W019032
PS-5566
2-Bromo-4-chloro-thieno[3,2-c]pyridine
EN300-6775188
QPGCPWZFCLBFCG-UHFFFAOYSA-N
A819687
Thieno[3,2-c]pyridine, 2-bromo-4-chloro-
2-Bromo-4-chlorothieno[3,2-c]pyridine
SC1601
SCHEMBL1774726
DTXSID50590481
FT-0646095
Thieno[3,2-c]pyridine,2-bromo-4-chloro-
2-bromo-4-chlorothieno[3,2-c]pyridine

MDL Number

MFCD08273916

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2-Bromo-4-chlorothieno[3,2-c]pyridine (CAS: 28948-61-0)?

2-Bromo-4-chlorothieno[3,2-c]pyridine is a crystalline solid with a molecular weight of approximately 266.03 g/mol. It has limited solubility in water but is more soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). The compound exhibits moderate reactivity, particularly towards nucleophiles and reducing agents. It shows good stability under dry conditions but may decompose at high temperatures or in the presence of moisture.

How is 2-Bromo-4-chlorothieno[3,2-c]pyridine (CAS: 28948-61-0) typically synthesized?

2-Bromo-4-chlorothieno[3,2-c]pyridine is commonly synthesized via the substitution of chlorine with bromine on the thieno[3,2-c]pyridine ring. This is typically achieved using bromine in the presence of a base such as sodium hydride in an anhydrous solvent like DMF. The reaction is selective and yields high purity product with good recovery rates.

What industries use 2-Bromo-4-chlorothieno[3,2-c]pyridine (CAS: 28948-61-0)?

2-Bromo-4-chlorothieno[3,2-c]pyridine is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the development of sensors due to its unique electronic properties. Additionally, it may be used in the synthesis of materials for semiconductor applications.

What precautions should be taken when handling 2-Bromo-4-chlorothieno[3,2-c]pyridine (CAS: 28948-61-0)?

When handling 2-Bromo-4-chlorothieno[3,2-c]pyridine, appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. The reaction should be conducted in a well-ventilated fume hood to minimize exposure to bromine and chlorine vapors. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly ventilated. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.