2-Bromo-4-chlorothieno[3,2-c]pyridine(CAS: 28948-61-0)

2-Bromo-4-chlorothieno[3,2-c]pyridine is a crystalline solid with a molecular weight of approximately 266.03 g/mol. It has limited solubility in water but is more soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). The compound exhibits moderate reactivity, particularly towards nucleophiles and reducing agents. It shows good stability under dry conditions but may decompose at high temperatures or in the presence of moisture.

2-Bromo-4-chlorothieno[3,2-c]pyridine is commonly synthesized via the substitution of chlorine with bromine on the thieno[3,2-c]pyridine ring. This is typically achieved using bromine in the presence of a base such as sodium hydride in an anhydrous solvent like DMF. The reaction is selective and yields high purity product with good recovery rates.

2-Bromo-4-chlorothieno[3,2-c]pyridine is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the development of sensors due to its unique electronic properties. Additionally, it may be used in the synthesis of materials for semiconductor applications.

When handling 2-Bromo-4-chlorothieno[3,2-c]pyridine, appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. The reaction should be conducted in a well-ventilated fume hood to minimize exposure to bromine and chlorine vapors. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly ventilated. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.