(2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid

Basic Information

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CAS Number

28697-17-8

Molecular Formula

C11H19NO4

Molecular Weight

229.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

116-119 °C

Boiling Point

353.2±35.0 °C at 760 mmHg

Flash Point

167.4±25.9 °C

Solubility

Soluble in 2ml dimethyl formamide 0.3gram.

Specific Rotation

68 º (c=1 in acetic acid)

SMILES

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CC(C)(C)OC(=O)N1CCCCC1C(=O)O

InChI

InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-7-5-4-6-8(12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m1/s1

InChIKey

JQAOHGMPAAWWQO-MRVPVSSYSA-N

LogP

1.8606

Topological Polar Surface Area

66.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

282

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

(R)-N-Boc-2-piperidinecarboxylic acid
boc-d-hopro-oh
JQAOHGMPAAWWQO-MRVPVSSYSA-N
(R)-1-(t-butoxycarbonyl)piperadine-2-carboxylic acid
(R)-(+)-N-Boc-2-piperidinecarboxylic acid, 98%
DS-1008
(R)-Piperidine-1,2-dicarboxylic acid 1-tert-butyl ester
(2R)-1-[(tert-butoxy)carbonyl]piperidine-2-carboxylic acid
(R)-(+)-1-(tert-Butoxycarbonyl)-2-piperidinecarboxylic acid
(R)-1-(t-butoxycarbonyl)piperdine-2-carboxylic acid
(R)-1-Boc-Piperidine-2-carboxylic acid
Z1143251655
(R)-(+)-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester
(2r)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-2-piperidinecarboxylic acid
MFCD00237380
CS-W014189
N-Boc-2(R)-piperidinecarboxylic acid
(R)-1-(tert-butoxycarbonyl)piperidine 2 carboxylic acid
Boc-D-Pip-OH
DTXSID70350923
Boc-(R)-(+)-piperidine-2-carboxylic acid
boc-d-piperidine-2-carboxylic acid
boc-d-homopro-oh
AS-37119
BB 0260100
(R)-(+)-N-Boc-2-piperidinecarboxylic acid
HMS1531H06
AC-24078
(R)-N-(t-butyloxycarbonyl)pipecolinic acid
n-boc-(r)-pipecolinic acid
SCHEMBL77858

MDL Number

MFCD00237380

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8)?

(2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8) is a white crystalline solid with a molecular weight of approximately 238.37 g/mol. It has a high solubility in organic solvents such as methanol and ethanol but is only slightly soluble in water. Reactivity is moderate, and it can participate in amide formation and esterification reactions. The compound is known for its stability under normal conditions, but care should be taken to avoid strong acids and bases that can alter its structure.

How is (2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8) typically synthesized?

(2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8) is typically synthesized through a multi-step process involving the formation of a piperidine ring followed by acylation. Common methods include the use of acyl chlorides or carboxylic acids with piperidine derivatives. The reaction is typically carried out in anhydrous conditions using a suitable solvent like dichloromethane, and the use of a catalytic amount of a base like triethylamine can enhance the yield and selectivity.

What industries use (2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8)?

(2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8) is used in various industries, including pharmaceuticals and drug discovery where it serves as a building block for synthesizing more complex molecules. It is also utilized in the polymer industry for developing new materials with specific properties. Additionally, this compound may find applications in the sensor technology sector for detecting specific chemical compounds, and in the semiconductor industry for its potential use in the fabrication of thin films and coatings.

What precautions should be taken when handling (2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8)?

When handling (2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be handled in a well-ventilated environment or under a fume hood to avoid inhalation. Spills should be cleaned up carefully, and the area should be well-ventilated. In case of accidental skin contact, wash the affected area with water and seek medical attention if necessary. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.