How is (2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8) typically synthesized?

(2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid (CAS: 28697-17-8) is typically synthesized through a multi-step process involving the formation of a piperidine ring followed by acylation. Common methods include the use of acyl chlorides or carboxylic acids with piperidine derivatives. The reaction is typically carried out in anhydrous conditions using a suitable solvent like dichloromethane, and the use of a catalytic amount of a base like triethylamine can enhance the yield and selectivity.